Cisplatin-Gemcitabine Related Cardiomyopathy in Non-Small Cell Lung Cancer NSCLC Patient: A Case Study
Journal Title: Journal of Case Reports and Studies - Year 2018, Vol 6, Issue 4
Abstract
Gemcitabine is a pyrimidine analog and cisplatin is a platinum agent, they are usually combined to form a chemotherapeutic doublet used to treat different types of oncological cancers, including non-small cell lung cancer (NSCLC). Although these agents are not known to cause such events, few cases related to possible cardiotoxicity side effects have been reported ; including angina, chronic heart failure, arrhythmias, and cardiac ischemia. A 52-year-old African male presented with Stage IV lung adenocarcinoma metastatic to the bone, pleura and lymph node, EGFR wild type. Patient has a history of hypertension, diabetes, and atrial fibrillation and on rate control medications. He was treated initially with cisplatin-gemcitabine, after which he developed cardiomyopathy. This was proven by a two-dimensional echocardiography with an ejection fraction dropping from 65% to 35%. In our perspective, cardiomyopathy could be related to cisplatin-gemcitabine, which is a rare but potential risk factor for developing cardiomyopathy especially if the patient has pre-existing comorbidities that may potentiate toxicity. An instant discontinuation with close monitoring is needed. Furthermore, we suggest considering other options of chemotherapy for patients if they develop cardiac adverse events.
Authors and Affiliations
Dawoud RA
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- EP ID EP584876
- DOI 10.15744/2348-9820.6.405
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