Citrus aurantifolia (Lime) Juice Negatively Influences Estrous Cycle of Wistar Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 1
Abstract
Citrus aurantifolia(Lime)fruit is commonly consumed and known to be rich in vitamins and other important phytochemicals. The effect of Limejuiceon estrous cycle was evaluated in female Wistar rats.Different groups of rats (n=6 per group) with regular estrous cyclesweregavaged orally with 1ml Lime juice (25, 50 or 100%) consecutively for fourteen days. A fourth (control) group was given distilled water.Vaginal lavage was analyzed daily in treated animals for ten days from the fourth day of administration to determine estrous cycle phases, but prior to juice treatment, estrous cyclesof rats were established. Animal body weights in treatment and control groups were monitored. Lime juice did not alter proestrus and estrus, but induced reduction (p=0.0271) in the durationofdiestrus phase. There was equally prolonged metestrus (p=0.0054) in animals that were exposed to Lime juice. Percentage of number of days in proestrus and metestrus were elevated after Lime juice treatment, while estrus and diestrus were decreased. This alteration in cyclicity was observed majorly intherats that received 50 and 100% concentrations. Furthermore, Lime juice treatment enhanced body weight gain, particularly the undiluted form. The results suggest that Citrus aurantifoliafruitjuice may alter estrous cycle and ultimately affect fertility in female rats.
Authors and Affiliations
Aprioku JS, Briggs OEI
Keywords
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