Clinical and experimental aspects of cutaneous neurogenic inflammation.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 1
Abstract
The aim of this paper is to present the state of knowledge on cutaneous neurogenic inflammation. Peripheral effector functions served by afferent sensory neurons underlie the so-called neurogenic inflammation. The mechanism of cutaneous neurogenic inflammation is connected with the release of neuropeptides from the sensory endings. They also exert a number of functions within the immune system. The activity of neuropeptides in the inflammation of the skin can be observed in the form of erythema, edema, hyperthermia and pruritus. Beside these peptides and their receptors, inflammatory skin response, is regulated by tryptase and proteinase-activated receptor 2 (PAR-2). Capsaicin decreases effects of inflammation-induced sensory neuropeptides, which was used in the treatment of diseases caused by inflammation. The activity of transient receptor potential vanilloid receptor 1 (TRP-V1) is associated with the neurogenic inflammation. In inflammatory processes, the neuro- immuno-cutaneous system undergoes activation, which is responsible for triggering and maintening the inflammatory conditions, both in the healthy skin as well as in the pathological conditions, like psoriasis. Skin exposure to UV radiation influences the neuro-immuno-cutaneous system and causes the release of neuropeptides, thereby eliciting inflammatory response in photodermatosis. In conclusion, understanding the mechanisms and the factors controlling neurotransmitters and their receptors will lead to the identification of novel therapeutic targets for the treatment of cutaneous diseases e.g. pruritus, psoriasis, alopetia areata.
Authors and Affiliations
Barbara Zegarska, Agnieszka Lelińska, Tomasz Tyrakowski
Keywords
Related Articles
- EP ID EP144334
- DOI -
- Views 117
- Downloads 0
Abstracts of the 20th Biennal Meeting of the ISN Satellite Symposium "MolecularBasis for Signal Transduction in Neurodegeneration and Neuroregeneration".
Cytoprotective effects of CSTMP, a novel stilbene derivative, against H(2)O(2)-induced oxidative stress in human endothelial cells.
A novel stilbene derivative, (E)-2-(2-chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP), was designed and synthesized based on the pharmacophores of tetramethylpyrazine (TMP) and resveratrol (RES). In the present study, we i...
Age-related macular degeneration (AMD): pathogenesis and therapy.
Age-related macular degeneration (AMD) is a disease leading to severe visual loss and legal blindness in the elderly population. Its pathogenesis, likely multifactorial, involving a complex interaction of metabolic, func...
Potential role of licofelone, minocycline and their combination against chronic fatigue stress induced behavioral, biochemical and mitochondrial alterations in mice.
Background: Chronic fatigue stress (CFS) is a common complaint among general population. Persistent and debilitating fatigue severely impairs daily functioning and is usually accompanied by combination of several physica...
Amino acid metabolic processes in the temporal lobes assessed by proton magnetic resonance spectroscopy ((1)H MRS) in children with Down syndrome.
Down syndrome (DS), or trisomy 21, is one of the most common autosomal mutations. The overexpression of the β-amyloid precursor protein gene, located on chromosome 21, causes an increased production of the specific amylo...