Clinical and histological evaluation of toluidine blue positive and negative stained oral mucosal lesions
Journal Title: Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology - Year 2016, Vol 2, Issue 3
Abstract
Introduction: Screening of suspicious oral precancerous lesions can aid in early detection of oral cancer thus reducing the mortality and morbidity associated with this condition. Incisional biopsy remains a gold standard for diagnosis of oral potentially malignant disorders. Toluidine blue is a basic metachromatic stain that demonstrates affinity for DNA and RNA. It offers a potentially simple, inexpensive, and sensitive chair-side solution for screening of early oral squamous cell carcinoma and highgrade dysplasias. The aim of this study was to assess the reliability of toluidine blue stain as clinical screening test, for presence of epithelial dysplasia in oral mucosal lesions. In this study, biopsy was done in patients with oral pre-malignant lesions to relate their toluidine blue status to outcome as well as to conventional histopathologic features. Method: Study Group consisted of 51 patients with potentially malignant oral mucosal lesions like homogenous leukoplakia (20), non-homogenous leukoplakia (16), erythroplakia (6), oral submucous fibrosis (5) and tobacco pouch keratosis (4). Patients were subjected to toluidine blue vital stain and were observed for positive and negative staining. Biopsy was taken from both toludine blue positive as well as negative lesions and graded for epithelial dysplasia to analyze the role of toludine blue staining in selecting lesions requiring biopsy.
Authors and Affiliations
Parul Khare Sinha, Madhvika Patidar, Vineet Raj, Shaleen Chandra, Nitin Agarwal
Keywords
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