Clinical and histopathological changes of some vital organs associated with intra-peritoneal experimental infection with Trypanosoma evansi in Guinea pigs
Journal Title: International Journal of Life Science and Agriculture Research - Year 2025, Vol 4, Issue 02
Abstract
The study was designed to evaluate clinico-pathological profiles associated with intra-peritoneal experimental infection with Trypanosoma evansi in Guinea pigs. Trypanosoma evansi or Surra is one of the protozoan diseases that inflict huge economic losses in the livestock industry. The causative agent of the disease is Trypanasoma evansi (T. evansi) which affects wide range of domestic and wild animals globally. Twenty guinea pigs (G. pigs) were purchased, screened and acclimatized. The G. pigs were randomly divided into two groups (A and B) of ten each. At day zero baseline data on haematology was established, to be sure that they are all free from any other parasites and some clinical parameters rectal temperature, body weight and clinical signs were observed and recorded. Animals in groups A were intraperitoneally (IP) inoculated with 0.5 ml of blood containing 1.0 × 106 Trypanosoma evansi as quantified using serial dilution, while group B were uninfected control. The observed clinical signs in the infected group were pale mucous membrane, anaemia, dullness, emaciation and loss of body weight. At postmortem, the gross changes observed included splenomegaly, hepatomegaly, congested lungs and enlarged kidneys and liver. Histopathological investigation revealed liver with multi-focal, vascular congestion and vacuolation, inflammatory cells infiltration around the central portal vein and the surrounding sinusoids. Similar changes were also observed in the kidneys, heart, spleen, and lungs of the infected guinea pigs In conclusion the infection had deteriorated the physiological status of the animals with clear cellular damage of some vital organs on the histopathological slides of the infected guinea pigs.
Authors and Affiliations
Abdullahi, Adama Musa. , Dauda, Iliyasu. , Umar, Muhammed Chafe. , Aminu, Ibrahim Daneji. , Musibau, Olayinka. Alayande
Keywords
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- EP ID EP759966
- DOI https://doi.org/10.55677/ijlsar/V04I02Y2025-12
- Views 26
- Downloads 0
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