Clinical and Laboratory Manifestations of Yemeni Patients with Systemic Lupus Erythematosus
Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 14, Issue 1
Abstract
Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by multi-systemic involvement. Tis is the frst study undertaken to determine the relationships between serological marker positivity and age, gender, signs and symptoms, risk factors and the treatment of SLE in Yemen. Methods: We investigated the cases of 149 patients with SLE admitted to Al-Tawra Hospital in Sana’a city between November 2009 and November 2010. Of the 149 patients, females represented 75.2% and males, 24.8%. Results: Te most frequent presenting signs and symptoms were fatigue (84.6%), fever (81.9%), arthropathy (81.2%), anaemia (64.4%), photosensitivity (54.4%), renal involvement (53%), malar rash (52.3%), and alopecia (49%). Antinuclear antibodies (ANA) were detected in 95.3% of the patients and were associated signifcantly with most clinical presentations, except weight loss, hypertension and serositis. Anti-ds deoxyribonucleic acid (anti-dsDNA) was detected in 59.7% of the patients, and was associated signifcantly with fever and fatigue. Anti-Smith (anti-Sm) antibodies were detected in 27.5% of the patients, but were not signifcantly associated with all clinical presentations. Social stress was the most important risk factor for inducing SLE, with an odds ratio (OR) of 6.0, followed by common exposure to sunlight (OR = 2.2). Conclusion: In this study, SLE was more prevalent among females and young adults. Te clinical presentation was characterised by a high incidence of fatigue and fever, and a low incidence of oral ulcers and serositis. ANA was associated with most clinical presentations except weight loss, hypertension, and serositis. AntidsDNA antibodies were most frequently associated with fever, fatigue and hypertension. Tere was no signifcant association of the anti-Sm antibodies with any clinical presentations.
Authors and Affiliations
Hassan A. Al-Shamahy| Department of Medical Microbiology & Immunology, Faculty of Medicine, Sana’a University, Sana’a, Yemen, Najla H. M. Dhaifallah| Department of Medical Microbiology & Immunology, Faculty of Medicine, Sana’a University, Sana’a, Yemen, Yahya M. Al-Ezzy| Department of Medical Microbiology & Immunology, Faculty of Medicine, Sana’a University, Sana’a, Yemen
Keywords
Related Articles
- EP ID EP14427
- DOI -
- Views 356
- Downloads 10
Gestational and Pregestational Diabetes Mellitus in Omani Women Comparison of obstetric and perinatal outcomes
Objectives: Te aim of this study was to assess the prevalence of gestational diabetes mellitus (GDM) and pregestational diabetes mellitus (PGDM) among pregnant women in Oman and compare their obstetric and perinatal ou...
Surgical Antimicrobial Prophylaxis Challenges in translating evidence to practice
Asymptomatic Ovarian Mucinous Cystadenoma with a Solid Mural Leiomyoma Case report and brief review
Mucinous neoplasms of the ovary may have associated benign or malignant mural nodules. A leiomyomatous mural nodule is a rare, benign lesion associated with mucinous tumors of the ovary. We report a case of a mural lei...
The History of Diabetes Mellitus
Diagnostic Screening Workflow for Mutations in the BRCA1 and BRCA2 Genes
Objectives: Screening for mutations in large genes is challenging in a molecular diagnostic environment. Sanger-based DNA sequencing methods are largely used; however, massively parallel sequencing (MPS) can accommodat...