CLINICAL AND MORPHOLOGICAL FEATURES OF HIV-ASSOCIATED TUBERCULOSIS
Journal Title: Ukrainian Scientific Medical Youth Journal / Український Науково-Медичний Молодіжний Журнал - Year 2013, Vol 71, Issue 1
Abstract
Tuberculosis in people living with HIV is an epidemic in the epidemic. HIV infection is among the most important risk factor for TB. For retrospective analysis of clinical, laboratory, and morphological features of co-infection with HIV / TB, we studied postmortem conclusion autopsies of patients who died during the period January to May 2011, the founding of the "Gomel Regional Tuberculosis Hospital."For the tasks were formed 2 groups. M ain group consisted of patients with HIV-related tuberculosis (30 people). In the control group were included HIV-negative tuberculosis patients (32 persons). Determined that the development of TB disease in HIV- infected takes place on 3 - 4 stages of HIV-infected (according to who classification, 2006). In patients with this pathology is observed more rapid course of TB in young age compared with HIV-negative patients. Most of the dead patients with HIV-associated tuberculosis were men at the age of 37,9 ± of 9.2 years. The length of the incidence of tuberculosis was of 1.77 ± of 3.2 years. In patients with HIV-associated tuberculosis morphological changes were more often in organs such as the lungs and liver. Significantly more prevalent following changes in lung plethora lung tissue (indicate part of the development of acute respiratory failure in patients coinfected with HIV / TB), bumps productively necrotic type and plethora of lung tissue (which shows the acute progressive form of TB-process), leukocytes in the lumen of the bronchi and bronchial epithelial desquamation (which confirms the acute progressive TB) process. The morphological changes of the liver tissue (p <0.05) were to focal fatty hepatocytes (which may be the result of long-term use of antiretroviral therapy), cusps productively necrotic type (which means part of the development of HIV-infected TB generalized infection) limfogistiotsitarnaya infiltration of the portal tracts (which is a manifestation of chronic hepatitis), hydropic degeneration of hepatocytes (which may be the result of protein-water-electrolyte metabolism in HIV¬ positive patients).
Authors and Affiliations
N. V. Burinsky, K. S. Borovikov
Keywords
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