Clinical and translational mode of single-cell measurements: clinical artificial intelligent single-cell
Journal Title: 中国临床医学（Chinese Journal of Clinical Medicine） - Year 2024, Vol 31, Issue 5
Abstract
With rapid development and maturity of single-cell measurements, single-cell biology and pathology has become an emerging discipline to understand the disease. However, it is important to address concerns raised by clinicians as to how to apply single-cell measurements for clinical practice, translate the signals of single-cell systems biology into determination of clinical phenotype, and predict patient response to therapies. This paper proposes a new system coined as the clinical artificial intelligent single-cell (caiSC) with the dynamic generator of clinical single-cell informatics, artificial intelligent analyzers, molecular multimodal reference boxes, clinical inputs and outputs, and AI-based computerization. This system provides reliable and rapid information for impacting clinical diagnoses, monitoring, and prediction of the disease at the single-cell level. The caiSC represents an important step and milestone to translate the single-cell measurement into clinical application, assist clinicians’ decision-making, and improve the quality of medical services. There is increasing evidence to support the possibility of the caiSC proposal, since the corresponding biotechnologies associated with caiSCs are rapidly developed. Therefore, we call the special attention and efforts from various scientists and clinicians on the caiSCs and believe that the appearance of the caiSCs can shed light on the future of clinical molecular medicine.
Authors and Affiliations
Xiangdong Wang, Powell Charles a. , Qin Ma, Jia Fan
Keywords
Related Articles
- EP ID EP749294
- DOI 10.12025/j.issn.1008-6358.2024.20241086
- Views 110
- Downloads 0
Expert consensus on clinical application of 177Lu-prostate specific membrane antigen radio-ligand therapy in prostate cancer
177Lu- prostate specific membrane antigen (PSMA) radio-ligand therapy has been approved abroad for advanced prostate cancer and has been in several clinical trials in China. Based on domestic clinical practice and experi...
The relationship between dietary fiber intake and hypertension: an analysis based on the NHANES data from 2015—2016 in the United States
ObjectiveTo explore the relationship between dietary fiber intake and hypertension in different populations. MethodsDietary fiber intake was calculated using the data from 2015—2016 National Health and Nutrition Examinat...
Predictive value of 3D quantitative shape features based on CT for disease-free survival of primary gastrointestinal stromal tumors
ObjectiveTo explore the predictive value of 3D quantitative shape features based on enhanced CT for disease-free survival (DFS) of primary gastric gastrointestinal stromal tumors (GIST) patients receiving curative resect...
The relationship between dietary fiber intake and hypertension: an analysis based on the NHANES data from 2015 — 2016 in the United States
Objective To explore the relationship between dietary fiber intake and hypertension in different populations. Methods Dietary fiber intake was calculated using the data from 2015—2016 National Health and Nutrition...
Value of one-stop spectral scanning of computer tomography pulmonary angiography combined with abdominal-pelvic enhancement in the pre-operative evaluation for patients with gynecologic tumors
ObjectiveTo explore the value of one-stop spectral CT scanning of computer tomography pulmonary angiography (CTPA) combined with abdominal-pelvic enhancement in preoperative evaluation for patients with gynecological tum...