Clinical Evaluation of Locally Delivered 10% Doxycycline Hyclate Gel as An Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 7
Abstract
To evaluate and compare the efficacy of locally administered 10 % doxycycline hyclate gel and scaling and root planing (SRP) in the treatment of chronic periodontitis. Randomized, controlled study was conducted involving 64 treatment sites in 32 patients suffering from chronic periodontitis. The selected two sites in each subject were randomized to two treatment groups: Group A – SRP + placement of 10% doxycycline gel immediately, and Group B – SRP alone. The gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline and subsequently after 1 month and 3 months. Significant improvement in GI and PI values in all the subjects were observed at 1 and 3 months (p<0.001) from baseline. Reductions in PPD values in Group A and Group B were significant (p <0.001) from baseline to 3 months, but was statistically non significant in Group B from 1 month to 3 months. Gain in CAL from baseline to 3 months was significant in both the groups (p<0.001), and was non significant (p =0.365) in Group B from 1 month to 3 months. On comparing Group A to Group B, reduction in PPD and gain in CAL were statistically significant (p <0.001) at the termination of study. SRP along with subgingival placement of doxycycline improves the clinical condition of periodontitis.
Authors and Affiliations
Dr. Shweta Aggarwal
Keywords
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