Clinical Evaluation of Multibacillary Leprosy Patients after Fixed Duration Multidrug Therapy (FD-MDT) of One Year: A Hospital Based Study
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Introduction: The fixed duration multidrug therapy (FD-MDT) of one year and relapses in multi-bacillary cases raise a few basic issues regarding the clinical activity and the bacillary index changes which occur in patients on multibacillary multidrug therapy. Aims and Objectives: The aim of the study was to assess the impact of FD-MDT of one year in terms of clinical improvement and changes in Bacillary Index (BI) of skin smear for acid fast bacilli (AFB), and to find out the patients who were at risk of relapse and therefore need prolonged follow up. Materials and Methods: In total of 100 multibacillary Leprosy patients, attending the urban leprosy Centre, who were on fixed duration multidrug therapy (FD-MDT), a hospital based study has been conducted. Patients were evaluated clinically by Ramu’s clinical score and bacteriological index was estimated by taking slit skin smear (SSS) using Ridley’s log scale. The clinical score and BI at the completion of FD-MDT of one year were compared with the scores at the time of Presentation. Results and Observations: The mean clinical score of 100 patients before treatment was 14.69 while as after treatment it became 7.25. The mean reduction in clinical score after 12 months of treatment was 7.44 which were found to be statistically significant. The mean bacterial indices of 100 patients before treatment was 3.29 while as after treatment it became 2.28, hence there was a reduction of 1.01 units in the mean bacterial indices at the completion of 1 year. The difference was statistically significant.
Authors and Affiliations
Gh Mohi ud Din Wani, Shabir ud Din Lone, Bilques Khursheed, Sheikh Imran Sayeed, Hilal Ahmad Wani
Keywords
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- EP ID EP531305
- DOI 10.21276/ijmrp.2018.4.1.132
- Views 111
- Downloads 0
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