Clinical features of mystania’s gravis course
Journal Title: Український неврологічний журнал - Year 2019, Vol 0, Issue 1
Abstract
Objective — to study the characteristics of the myasthenia gravis development in patients related to age, sex, first symptoms, the duration of diagnosis setting. Methods and subjects. 182 patients with myasthenia gravis were examined from 2014 to 2017 : 147 (80.8 %) patients with a generalized form, 35 (19.2 %) — with ocular form. Clinical and neurological examination was done, which included the collection of complaints, history of disease and life, neurological examination. To evaluate the clinical form of myasthenia gravis, the MGFA classification was used. Results. Among patients, women prevailed — 128 (70.3 %), compared with men — 54 (29.7 %), the ratio of women to men — 2.37 : 1. The mean age of patients with the generalized form of myasthenia is 53.0 (37.0; 65.0) years, with ocular form — 46.0 (23.0; 62.0) years, p = 0.023. Women have 2 peaks of the disease debut — the 1st — highest at the age range of 20 to 40 years (39.9 % of the surveyed) and 2nd at the age of 50 to 70 years (32.0 %). Men have one peak of the first symptoms at the age range of 50 to 70 years (46.3 %). In the structure of the first symptoms double vision prevailed with a frequency of 36.3 % (95.0 % CI 29.3 — 43.2), in the second place — ptosis (28.6 % (95.0 % CI 22.0 — 35.1)) followed by weakness and/or fatigue in the limbs (21.4 % (95.0 % CI 15.5 — 27.4)), nasal voiding (14.3 % (95.0 % CI 9.2 — 19.4)) and choke on food (14.3 % (95.0 % CI 9.2 — 19.4)). The most rarely reported debut symptoms were chewing disorders (1.6 % (95.0 % CI (‑0.2 — 3.5)). Conclusions. Myasthenia gravis in women debutes at a significantly younger age compared with men. The ocular form of myasthenia gravis is more typical for young people, and it takes shorter time period to diagnose it compared with generalized form. Two peaks of the myasthenia debut were discovered: early (20 — 40 years) — typical for females and late (50 — 70 years) — typical for patients of both sexes. Often, myasthenia gravis debuts with double vision, ptosis, and most rarely — with a violation of chewing. In the vast majority of patients myasthenia debuted mono symptoms (81.3 % of cases), rarely — bisymptoms (18.7 %).
Authors and Affiliations
O. I. Kalbus, V. M. Shkolnyk
Keywords
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- EP ID EP594402
- DOI 10.30978/UNJ2019-1-10
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