Clinical observation of Shengxuebao Mixture in treating anemia after concurrent chemoradiotherapy for cervical cancer
Journal Title: TMR Clinical Research - Year 2021, Vol 4, Issue 2
Abstract
Objective: To investigate the efficacy of the Shengxuebao Mixture in treating anemia after concurrent chemoradiotherapy for cervical cancer. Methods: The patients who met the criteria were randomly divided into the study group (n = 30) and the control group (n = 30). The study group was treated with Shengxuebao Mixture （15 ml once, three times a day） for 30 days, and the control group was treated with ferrous succinate tablets (0.1 g, twice a day), folic acid tablets (5 mg, three times a day), and vitamin B12 tablets (25 μg, once a day) for 30 days. Observed the hemoglobin level, erythropoietin level, TCM syndrome score, karnofsky performance status score before and after treatment in the two groups, compared the relevant data and clinical efficacy between the two groups and observed the adverse drug reactions at the same time. Results: The age, pathological type, stage, baseline hemoglobin level, erythropoietin level, TCM syndrome score, and karnofsky performance status score were comparable between the two groups (P > 0.05). The hemoglobin level of the two groups after treatment was higher than before treatment (P < 0.05). After treatment, the hemoglobin level in the study group was significantly higher than that in the control group (P < 0.05), and the number of effective cases in the study group was more than that in the control group, and the effective rate in the study group was higher than that in the control group (P < 0.05). The erythropoietin level of the two groups after treatment was lower than before treatment (P < 0.05). After treatment, the erythropoietin level in the study group was significantly lower than that in the control group (P < 0.05). The TCM syndrome score of the study group decreased significantly after treatment (P < 0.05), but there was no significant change in the control group (P > 0.05). After treatment, the TCM syndrome score of the study group was significantly lower than that of the control group (P < 0.05), and the number of effective cases in the study group was more than that in the control group, and the effective rate in the study group was higher than that in the control group (P < 0.05). There was no significant change in the karnofsky performance status score of the study group after treatment (P > 0.05), but the karnofsky performance status score of the control group decreased significantly (P < 0.05). After treatment, the karnofsky performance status score of the study group was higher than that of the control group (P < 0.05), and the number of effective cases in the study group was more than that of the control group, and the effective rate was higher than that of the control group (P < 0.05). And there were no obvious adverse reactions in this study. Conclusion: To some extent, this study showed that the Shengxuebao Mixture has a definite effect in treating anemia after concurrent chemoradiotherapy for cervical cancer, can promote the use of erythropoietin, improve TCM syndromes and stabilize the quality of life of patients.
Authors and Affiliations
Kai Zhou1, Jia-Yu Zhang1, Xi-Wei Yang1, Da Shen2, Jun-Jin Li3, Yan-Fang Cheng3, Xiao-ling Qian3, Pei-Xian Zhang3, 4*
Keywords
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- EP ID EP695488
- DOI 10.12032/TMRCR20210507005
- Views 153
- Downloads 0
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