Clinical Outcome of Tamoxifen and Sulindac for Desmoid Tumors in Adults: A Phase II Single Institution Experience
Journal Title: Middle East Journal of Cancer - Year 2019, Vol 10, Issue 2
Abstract
Background: Desmoid tumors are rare soft tissue neoplasms that have a variable and often unpredictable clinical course. We have conducted a phase II study to evaluate the efficacy and safety of tamoxifen and sulindac in treatment of primary unresectable and recurrent desmoid tumors. Methods: Eligible patients were ≥18 years of age who had measurable histologically confirmed recurrent or newly diagnosed tumors not amenable to R0 resection, or those who underwent tumor excision with gross residual desmoid tumor. The primary objective was to estimate progression-free survival. Patients received 20 mg tamoxifen and 300 mg sulindac daily for up to 12 months according to absence of disease progression or unacceptable drug toxicity. Results: 25 patients, 12 males and 13 females, whose ages ranged from 18-60 years. Most (88%) had a good performance status (ECOG 1). A total of 6 of 15 patients with recurrent desmoid tumors had histories of prior local radiotherapy for their primary tumors. There were 10 newly diagnosed patients, 15 (60%) had recurrent disease and only one patient had a diagnosis of familial adenomatous polyposis. Only 22 patients completed the treatment protocol and were evaluated for clinical response and time to progression. All patients were evaluated for safety profile. The overall response rate was 60%, with complete response observed in 8% and partial response in 52%. At two years, the estimated progression-free survival rate was 55% with a median progressionfree survival of 25 months. Conclusion: According to the results of this study, systemic treatment with tamoxifen and nonsteroidal anti-inflammatory drugs is safe and effective in patients with desmoid tumors.
Authors and Affiliations
Abeer Hussien Anter, Rasha Mohamed Abdel-Latif
Keywords
Related Articles
- EP ID EP638885
- DOI 10.30476/mejc.2019.78543.
- Views 96
- Downloads 0
Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran
Background: Records from the cancer registry system of Iran indicate that colorectal cancer is the third most common cancer in Iranian men and fourth most common among Iranian women. In this study we have investigated th...
Patients’ Experiences with the Degenerative Process of Cancer: A Content-analysis Study in Iran
Background: This study sought to provide a comprehensive understanding of cancer treatment refusal based on the experiences of patients, caregivers, and health care providers. Methods: In this qualitative research study,...
Clinical Significance of BRAF and ZEB2 Expressions in Healthy Adjacent Tissue of Bladder Cancer
Background: Numerous molecular changes are involved in the development and progression of bladder cancer. Regular follow-up of patients is crucial due to the high recurrence rate of bladder cancer. The aim of this study...
The Life and Works of Sadid al-Din Kazeroni: An Iranian Physician and Anatomist
Background: One of the great physicians in Iran who had expertise in medicine, surgery, and pharmacy was Sadid al-Din Kazeroni. He was a 14th century physician. No information is available on his birth and death – only “...
An Immunohistochemical Study of Vascular Endothelial Growth Factor Expression in Meningioma and Its Correlation with Tumor Grade
Background: Meningiomas are one of the most common primary brain tumors and the most common intradural spinal tumors. Vascular endothelial growth factor has been demonstrated to play an important role in the stimulation...