Clinical Presentation and Histopathological Profile and Renal Outcome of ANCA Associated Vasculitis
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 10
Abstract
Background: Antineutrophil cytoplasmic antibody (ANCA) associated vasculitides usually affect various organ systems. Renal involvement usually presents as rapidly progressive renal failure. The clinicopathological variants are Microscopicpolyangitis, Granulomatosis with polyangitis and renal limited vasculitis. Aim: To study the epidemiological, clinical profile of ANCA associated vasculitis clinico- histo pathological correlation and renal outcome after treatment. Materials & Methods: Retrospective and prospective observational study from June 2015 to May 2018. Patients with active vasculitis, ANCA positive serology and necrotizing/ crescentic pauci immune glomerulonephritis in biopsy were included. Patients aged<13 years, normal urine analysis and normal serum creatinine were excluded. Observation & Conclusion: ANCA associated glomerulonephritis contributed to 2.8% of native kidney biopsies. Common age group was between 51 -60 years. The median age of presentation was 45±10.9 years. Male to female ratio was 1:1.6. 24(61.5%) patients had microspicpolyangitis (MPA), 11 (28%) patients granulomatosis with polyangitis (GPA), four had renal limited vasculitis. Six patients (15%) had ANCA negative vascultis. Joint involvement predicted the renal prognosis of ANCA vasculitis in this study. Sclerotic subtype of ANCA associated vasculitis had poor renal prognosis.
Authors and Affiliations
Dr C. Padmakumar
Keywords
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