CLINICAL PROFILE, EPIDEMIOLOGY AND PROGNOSTIC FACTORS IN SCRUB TYPHUS

Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 21

Abstract

BACKGROUND Scrub typhus is an underdiagnosed disease, but potentially treatable, if diagnosis is made with high index of suspicion. Deaths are attributable to late presentation, delayed diagnosis and drug resistance. MATERIALS AND METHODS The study was an observational study of prospective design conducted in the Department of General Medicine, Government Medical College, Kozhikode, over a period of one year. History, physical examination and relevant lab investigations were done in 70 patients in the study. RESULTS Majority of patients were in working class. Most common physical finding was lymphadenopathy. Eschar was present in 46% of patients. Majority responded to doxycycline. Case fatality was 14.3%. CONCLUSION 1. Most cases occurred during cooler months of the year (Oct-Feb). 2. Fever and headache were the most common symptoms. 3. Lymphadenopathy was the most common sign followed by splenomegaly. 4. Eschar was present in 46% cases. 5. Leucocytosis was associated with poor prognosis and increased complication like meningoencephalitis. 6. Hypoalbuminaemia was associated with increased incidence of complications like myocarditis and encephalitis. 7. More than 2 times, elevation of transaminases was a poor prognostic marker. 8. Most common and important complication was Acute Kidney Injury (AKI). 9. Microangiopathic haemolysis could possibly be a contributory factor for high incidence of AKI associated with scrub typhus. 10. Rampant NSAID use is another contributory factor for high incidence of AKI associated with scrub typhus. 11. Resistance to doxycycline is emerging in our community and we should consider this possibility in cases with strong suspicion with no response to doxycycline.

Authors and Affiliations

Priyadarshini B, Jayesh Kumar P, Anitha P. M

Keywords

Related Articles

OCULAR DISORDERS IN CHILDREN WITH DEVELOPMENTAL DELAY

BACKGROUND In India, an estimated 1.5-2.5% children below 2 years of age are developmentally delayed. A higher incidence of ocular disability is seen in these children, refractive errors and strabismus being most common....

SUBCLINICAL HYPOTHYROIDISM IN METABOLIC SYNDROME AND ROLE OF CRP IN 50 ADULT PATIENTS

BACKGROUND Metabolic Syndrome (MetS) is generally characterised as a clustering of the abnormal levels of blood lipids (low HDL and high triglycerides), impaired fasting glucose, elevated blood pressure, and excess abdom...

ROLE OF CORTICAL MASTOIDECTOMY IN INACTIVE, MUCOSAL TYPE OF CHRONIC OTITIS MEDIA

Chronic Otitis Media still remains a major health problem in our country. The management of Chronic Otitis Media with or without cholesteatoma, is probably the most common reason why the simple mastoid operation is perfo...

PHACOEMULSIFICATION VERSUS MANUAL SMALL INCISION CATARACT SURGERY AT SUBDISTRICT HOSPITAL, SOPORE, KASHMIR

BACKGROUND The aim of this study was to compare the results of phaco-emulsification cataract surgery and manual small-incision cataract surgery. MATERIALS AND METHODS A prospective randomized controlled trial was carried...

CLINICO-ANATOMICAL VARIATIONAL STUDY OF CHRONIC RHINOSINUSITIS

BACKGROUND Rhinosinusitis is an infection of nose and paranasal sinuses (PNS) which is influenced by host and environmental factors and is the commonest problem encountered in ENT Clinics. Anatomical variations will affe...

Download PDF file
  • EP ID EP215216
  • DOI 10.18410/jebmh/2017/241
  • Views 104
  • Downloads 0

How To Cite

Priyadarshini B, Jayesh Kumar P, Anitha P. M (2017). CLINICAL PROFILE, EPIDEMIOLOGY AND PROGNOSTIC FACTORS IN SCRUB TYPHUS. Journal of Evidence Based Medicine and Healthcare, 4(21), 1224-1226. https://www.europub.co.uk/articles/-A-215216