Clinical study of HELLP syndrome in tertiary care Hospital
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 4
Abstract
Introduction: Every woman’s wish is to end her pregnancy with a healthy baby and a healthy mother. Unfortunately, some women develop pregnancy induced hypertension sometimes ending in its dreaded complications. PIH is one among the leading causes of maternal and perinatal morbidity and mortality. It has higher prevalence in nulliparous and is present as a maternal syndrome, characterized by arterial hypertension generally with Proteinuria, and a foetal syndrome, with foetal growth restriction and amniotic fluid reduction. It may have several systemic manifestations, variable degrees of severity and either an early onset with maternal and foetal morbidity, or a late onset, near term, with less severity and reduced foetal compromise. Preeclampsia is characterized by hypertension (systolic and diastolic blood pressure of ≥ 140 and 90 mm Hg, respectively, on two occasions, at least 6 hours apart) and Proteinuria (protein excretion of ≥ 300 mg in a 24 h urine collection, or a dipstick of ≥ 1+), developing after 20 weeks of gestation in previously normotensive women. The analysis of the physio-pathological process shows that its origins are related to an immunological process associated with a defective and insufficient placentation.Although the placental origins of the disease are largely accepted maternal or foetal predisposing factors are also considered when an early onset or a high severity are present. Aim and Objectives: To study the maternal outcome and perinatal outcome in pregnancy complicated with HELLP syndrome. Materials and Methods: An observational study identified 50 cases of HELLP syndrome from a total of 7352 deliveries over a 22 months period. Results: The mean maternal age was 26.73 years with HELLP syndrome diagnosed. There were 29 cases of partial HELLP syndrome & 21 cases of complete HELLP syndrome. The average platelet was 53000 with elevated liver enzymes in all cases.23 (46%) were posted for Caesarean section and 27(54%) delivered by vaginal route. There were 4 maternal deaths, 13 stillbirth and 7 neonatal deaths. Conclusion: HELLP syndrome is an obstetric complication. Early diagnosis and treatment is main stay of management. Use of corticosteroids improves in lab parameters, better maternal and perinatal outcome.
Authors and Affiliations
Dr. Vivek Hoskeri, Dr. R Patange, Dr. Nitin Kshirsagar, Dr. Sanjay Patil, Dr. Anjali Patil, Dr. Snehal Shinde
Keywords
Related Articles
- EP ID EP584859
- DOI -
- Views 144
- Downloads 0
Triple negative breast cancer: A therapeutic challenge
Triple negative breast cancer (TNBC) is special subgroup of breast cancer accounting for 15-25%, with clinico-pathological heterogenesity, aggressive course and limited treatment options making clinical management challe...
Study of umbilical cord blood culture in diagnosis of early-onset sepsis among newborns with high-risk factors
Introduction: Neonatal sepsis is most common cause of neonatal mortality. Umbilical cord is a less commonly used site for collection of blood culture. Objectives: To analyze correlation of UCBC (Umbilical Cord Blood Cult...
A study of evaluation of histopathological spectrum of lymph node lesions in a tertiary care centre
Objectives: Lymph nodes are involved in immune response of the body. The underlying cause of lymphadenopathy may range from a treatable infectious etiology to a malignant neoplasm. Excision biopsy of the lymph node provi...
Clinical assessment of varicose veins patients undergoing surgery
Varicose veins and their associated symptoms and complications constitute the most common chronic vascular disorders leading to surgical treatment. The term varicosity is generally applied to elongated, tortuous, pouched...
Antibiogram in tertiary care centre
A total 100 samples of patients with chronic suppurative otitis media (C.S.O.M.) were studied bacteriologically. Ear infection was found to be more common in paediatric population (70.96%). Males suffered more than femal...