Clinical study of the treatment effects of direct current iontophoresis of triamcinolone acetonide on oral submucous fibrosis
Journal Title: 口腔疾病防治 - Year 2019, Vol 27, Issue 10
Abstract
Objective To observe the clinical effects of direct current iontophoresis (DCI) of triamcinolone acetonide (TA) on treatment of oral submucous fibrosis. Methods Fifty-one patients were randomly divided in group A (n=25), which underwent local submucous injection with TA (20 mg for each side) once a week for 8 weeks, and group B (n=26), which underwent local TA administration by DCI (20 mg for each side) for 8 weeks, follow-up was performed 12 weeks after treatment. The distances between the upper and lower central incisors were recorded. The visual analogue scale (VAS) was used to evaluate the pain caused by the two treatments. The Oral Health Impact Profile (OHIP)-14 was used to assess the entire effect of treatments. Results At 8 weeks of treatment, the mouth opening was increased by 3.25 ± 0.77 mm in group A and 3.76 ± 0.88 mm in group B (P＜ 0.05). At 20 weeks after treatment, the mouth opening was increased by 2.61 ± 0.62 mm in group A and 2.53 ± 0.52 mm in group B (P > 0.05). After the first treatment, the VAS score of group A was 7.88 ± 0.80, and the VAS score of group B was 2.47 ± 0.64, resulting in a statistically significant difference (P＜ 0.001). After the last treatment, the VAS score was 7.29 ± 0.53 in group A and 1.77 ± 0.48 in group B, resulting in a statistically significant difference (P＜ 0.001). The VAS scores of the two groups were decreased after treatment, and the difference between groups was statistically significant (P＜ 0.001). The OHIP-14 score of patients in group A before treatment was 31.44 ± 2.55, while that in group B was 32.04 ± 2.20 (P > 0.05). At 20 weeks after treatment, the score in group A was 13.52 ± 3.31 and that in group was 12.04 ± 2.84 (P > 0.05). The OHIP-14 scores of the two groups were significantly decreased before and after treatment, and the difference between groups was statistically significant (P＜ 0.001). Conclusion The results suggest that local TA administration by DCI might be a promising method for treatment in the early and middle disease periods in OSF patients.
Authors and Affiliations
PENG Haiyan, JIANG Xiaowen, FU Zhimin, HUANG Huaqin, CHEN Jinyong
Keywords
Related Articles
- EP ID EP672949
- DOI 10.12016/j.issn.2096-1456.2019.10.005
- Views 179
- Downloads 0
Establishment and analysis of a diagnosis and treatment database of dental and maxillofacial deformities
Objective To establish the first dento-maxillofacial deformity diagnosis and treatment database in China, provide reference for the clinical diagnosis and treatment of dento-maxillofacial deformity in China, and lay the...
Application of digital technology in orthodontic clinic
The rapid development of digital technology has made the processes of orthodontic data collection, diagnosis, design and treatment more accurate, comprehensive, convenient and safe and has improved the clinical efficienc...
A comparison of the effect of different nickel-titanium instruments combined with ultrasonic irrigation on root canal preparation
Objective To compare the removal efficiency and the amounts of apically extruded debris using Twisted File (TF), Twisted File Adaptive (TFA), ProTaper, and ProTaper Next combined with ultrasonic irrigation and to provide...
Effects of silencing the HIF-1α gene on the expression of BSP and osterix in rat BMMSCs under tension
Objective To explore the effect of hypoxia inducible factor 1α (HIF-1α) gene silencing in rat bone marrow mesenchymal stem cells (BMMSCs) under mechanical distraction on the expression of bone sialoprotein (BSP) and oste...
Application of extended clavicular epithelial flap in postoperative defect repair in elderly patients with oral cancer
Objective To explore the clinical application of an extended clavicular epithelial flap with a transverse cervical arterial blood supply in the repair of postoperative soft tissue defects in elderly patients with oral ca...