CLINICO-HAEMATOLOGICAL AND BIOCHEMICAL PROFILE OF DIMORPHIC ANAEMIA WITH BONE MARROW STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 19
Abstract
BACKGROUND Dimorphic anaemia is very common in India. Dimorphism indicates the presence of two distinct populations of red cells. The term is most often applied when there is one population of hypochromic, microcytic cells and another population of normochromic cells, either normocytic or macrocytic. Aims and Objectives1. Dimorphic anaemia has been studied, because treatment may be ineffective if the dual deficiency is not diagnosed. 2. To correlate and compare the clinico-haematological, biochemical parameters with bone marrow study. 3. To find out the clinical and haematological features of severe anaemia with bone marrow study. MATERIALS AND METHODS This descriptive study included 51 cases of dimorphic anaemia to evaluate association of biochemical profile of dimorphic anaemia with bone marrow study. Data collected from case files, patient history, clinical profile, peripheral blood findings, haematological parameters, bone marrow aspiration and biochemical parameters. RESULTS In our study, dimorphic anaemia (DA) was mostly found in 15 - 30 years of age. The male-to-female ratio was 1.5: 1 in our study. The most common clinical presentation was pallor and generalised weakness (100%) followed by easy fatigability (72.5%), fever (54.90%), altered behaviour (19.6%) and tingling (8%) are found. Bleeding (13.7%), itching and red spots (13.7%) are found in patients having thrombocytopenia. DA was found mostly in vegetarians (62.7%). The mean haemoglobin was 6.6 gm/dL. Splenomegaly and hepatomegaly were present in 35.2% and 23.5% respectively. There was complete correlation between three parameters in 8/51 (15.68%) cases only. CONCLUSION Bone marrow examination provides rapid and cost-effective investigation for confirming the diagnosis of dimorphic anaemia by reliably assessing the iron stores. Serum ferritin is more specific in predicting the iron deficiency. Serum vitamin B12 and serum folate are also specific, but not sensitive.
Authors and Affiliations
Sonu Rawat, Rajni Choudhary, Nigam R. K
Keywords
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- EP ID EP418201
- DOI 10.14260/jemds/2018/527
- Views 107
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