Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes
Journal Title: Journal of Applied Veterinary Sciences - Year 2021, Vol 6, Issue 2
Abstract
This study aimed to investigate the effect of Ivermectin (IVM) on the reproductive hormones and hemato-biochemical parameters of twenty apparently healthy ewes weighing 30-40 kg and 2-3 years old. Ewes were randomly divided into two groups (ten for each). The first group was left without treatment (control group), and the second was treated with the recommended therapeutic dose of IVM (0.2 mg/kg, S/C) one day after parturition (treated group). The study continued for three months. Blood samples were collected from the two groups at the 1st, 30th, 60th, and 90th days after IVM treatment. The current study revealed that IVM injection delayed estrous for up to 3 months (absence of estrous signs and no ovarian structures were observed by sonar examination). There was a significant decrease in hemoglobin concentration (Hb), red blood cells (RBCs) count, and packed cell volume (PCV), with a significant increase in total leukocytic count (TLC) at 30th and 60th days post-treatment (p.t.). In addition to a significant decreased at (P<0.05) in the activity of glutathione peroxidase (GSH) and concentrations of total antioxidants (TAC), copper (Cu), phosphorus (P), estradiol, triiodothyronine(T3), and tetraiodothyronine (T4) for up to 3 months. In contrast, a significant increase in concentrations of calcium (Ca), progesterone and cortisol, and activity of malondialdehyde (MDA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) enzymes were recorded at 30th and 60th days p.t. It has been concluded that IVM delayed estrous in ewes for three months via disturbing the female reproductive hormones and the hemato-biochemical parameters. Therefore, it is recommended that IVM not be injected at least three months before the reproductive season.
Authors and Affiliations
Ghada H. Abdel-Rahman, Amal H. Ali
Detection Limits Of Live Attenuated Poultry Viral Vaccine Testing Method For Detection Of Bacterial Contamination
A total number of 27 vaccine vials including 3 batches of 3 different types of live attenuated poultry viral vaccines (tissue culture Gumboro vaccine, egg adapted colored ILT vaccine and egg adapted noncolored ILT vaccin...
Isolation and Molecular Characterization of Equine herpes virus-1 from Horses Localized in Giza Governorate, Egypt
Equine herpesvirus-1 (EHV-1) is endemic in many world areas, including Egypt with significant economic losses in the equine industry through causing a high fatality rate among foals associated with respiratory manifestat...
A Survey on Congenital Head Malformations in Calves
Congenital malformations are structural and functional abnormalities that present at birth. Congenital head malformations were present in 231 (22 bovine and 209 buffalo) calves referred to Mansoura veterinary teaching ho...
A Comparative Study On Biochemical Parameters For Mature California And Chinchilla Rabbits In Sohag Governorate.
Rabbit as homeothermic species is able to keep its core body temperature within ± 1°C regulatory range. In Upper Egypt where high ambient temperature particularly at summer months, rabbit breeding ceases, by virtue of it...
Preparation Of Inactivated Infectious Bursal Disease Virus Vaccine From Classical Strain And Local Variant Isolates
This study was conducted to assess an inactivated vaccine prepared from local field isolates of Infectious Bursal Disease (IBD) "local variant and virulent isolates" and a classical strain "bursa vacc" to improve the ful...