Clinicopathological features of orbital extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue: a series of 71 cases
Journal Title: Eye Science (Yanke Xuebao) - Year 2021, Vol 36, Issue 9
Abstract
[Objective:] To investigate the clinical, imaging and pathological features of orbital extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT), so as to reduce misdiagnosis and improve survival rate. [Methods:] The clinical, imaging and histopathological data of 71 patients with orbital extranodal marginal zone B cell lymphoma of MALT who were treated in Zhongshan Ophthalmic Center, Sun Yat-sen University from Jan.2020 to Dec. 2020 were retrospectively analyzed. [Results:] There were 38 males and 33 females in the 71 patients. There were 31 cases located on the left orbit, 34 cases on the right orbit, and 6 cases were bilateral; there were 67 primary cases and 4 relapsed cases. The age ranged from 23 to 84 years old. The disease course ranged from 3 months to 15 years. The main clinical manifestations included ocular masses and limited eyeball movement. Magnetic resonance imaging showed a “cast-like” soft tissue shadow of uniform density, and no intraocular invasion is observed. Histopathological examination showed that the tumor was composed of small to medium sized lymphocyte-like cells. Tumor cells exhibited diffuse or lamellar growth, with small to medium-sized irregular nuclei, and the nucleoli were inconspicuous. Some of the lymphocyte-like cells showed mononuclear lymphoma cells changes, and plasmacytoid differentiation was observed in 9 cases, in which kappa and lambda expressions were asymmetric. [Conclusion:] The clinical manifestations of orbital extranodal marginal zone B cell lymphoma of MALT are various, and imaging examination has certain characteristics, which can assist preoperative diagnosis. Pathological examination can be used for accurate diagnosis and classification after operation, based on which appropriate treatment plan can be made and curative effect can be improved.
Authors and Affiliations
Lijuan TANG, Wenxin ZHANG, Huanhuan GAO, Shuxia CHEN, Jianxian LIN, Yongping LI, Ping ZHANG
Keywords
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- EP ID EP763562
- DOI 10.3978/j.issn.1000-4432.2021.08.12
- Views 16
- Downloads 0
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