Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects
Journal Title: Jornal de Pediatria - Year 2017, Vol 93, Issue 1
Abstract
Objective Evidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome. The aim of this study is to evaluate the coenzyme Q10 and selected pro-inflammatory markers such as interleukin 6 and tumor necrosis factor α in children with Down syndrome. Methods Eighty-six children (5–8 years of age) were enrolled in this case-control study from two public institutions. At the time of sampling, the patients and controls suffered from no acute or chronic illnesses and received no therapies or supplements. The levels of interleukin 6, tumor necrosis factor α, coenzyme Q10, fasting blood glucose, and intelligence quotient were measured. Results Forty-three young Down syndrome children and forty-three controls were included over a period of eight months (January–August 2014). Compared with the control group, the Down syndrome patients showed significant increase in interleukin 6 and tumor necrosis factor α (p=0.002), while coenzyme Q10 was significantly decreased (p=0.002). Also, body mass index and fasting blood glucose were significantly increased in patients. There was a significantly positive correlation between coenzyme Q10 and intelligence quotient levels, as well as between interleukin 6 and tumor necrosis factor α. Conclusion Interleukin 6 and tumor necrosis factor α levels in young children with Down syndrome may be used as biomarkers reflecting the neurodegenerative process in them. Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.
Authors and Affiliations
Angie M. S. Tosson
Keywords
Related Articles
- EP ID EP510518
- DOI 10.1016/j.jped.2016.04.012
- Views 81
- Downloads 0
Pediatric abdominal non-Hodgkin's lymphoma: diagnosis through surgical and non-surgical procedures
Objective To describe the success rate and the complications after procedures to diagnose abdominal non-Hodgkin's lymphoma in children and adolescents. Methods A retrospective cross-sectional study was conducted with a...
Pediatric chronic patients at outpatient clinics: a study in a Latin American University Hospital
Objective To describe the characteristics of children and adolescentes with chronic diseases of outpatient clinics at a tertiary university hospital. Methods A cross-sectional study was performed with 16,237 patients wi...
Who cares for adolescents and young adults with cancer in Brazil?
Objective Approximately 6% of all cancers arise in adolescents and young adults. Currently, the ward type best placed to treat this patient group remains controversial. The aim of this study was to evaluate exactly where...
Prevalence and factors associated with breast milk donation in banks that receive human milk in primary health care units
Objective To estimate the prevalence and to analyze factors associated with breast milk donation at primary health care units in order to increase the human milk bank reserves. Methods Cross-sectional study carried out...
Practices related to late-onset sepsis in very low-birth weight preterm infants
Objective To understand the practices related to late-onset sepsis (LOS) in the centers of the Brazilian Neonatal Research Network, and to propose strategies to reduce the incidence of LOS. Methods This was a cross-sect...