COLLECTION, PURIFICATION AND PHYTOCHEMICAL SCREENING OF A NATURAL GUM FOR ORAL CONTROLLED DRUG DELIVERY SYSTEM
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 6
Abstract
Present study highlighted that sustained release matrix tablet of Indomethacin using gum karaya (GK) as matrix former. Various concentrations of KG used to ensure the release model. Preformulation study of Indomethacin was done initially and results directed for the further course of formulation. Based on preformulation studies different batches of tablet have been prepared by wet granulation method by using selected excipients. Granules were evaluated for various tests before being punched as tablets. Tablets were tested for weight variation, thickness, hardness and friability as per official procedure. Dissolution of batch F1 – F6 were carried out in phosphate buffer pH 6.8 media. In vitro dissolution test reveal that is dependent upon the nature and concentration of the polymer. It was concluded that F3, F5 and F6 shown best drug release profile after12 hours i.e. 92.39%, 98.54% and 93.525% respectively and the release seem to obey the Higuchi kinetic model and were finally optimized.
Authors and Affiliations
Jyotirmoy Deb*| Department of Pharmaceutics, S. Chaavan College of Pharmacy, Nellore, Andhra Pradesh, Mrinmay Das| Department of Pharmaceutics, S. Chaavan College of Pharmacy, Nellore, Andhra Pradesh, Arup Das| Department of Pharmaceutics, S. Chaavan College of Pharmacy, Nellore, Andhra Pradesh, P. Mohonraj| Department of Pharmaceutics, S. Chaavan College of Pharmacy, Nellore, Andhra Pradesh, Arwan Raplang Lyngdoh*| Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, Sikkim, India, Sujit Das| Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, Sikkim, India, Amitava Roy| Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, Sikkim, India
Keywords
Related Articles
- EP ID EP3776
- DOI -
- Views 420
- Downloads 18
HEMATOPOIETIC GROWTH ASPECTS: MANIFESTATION OF VULNERABILITIES AND PROSPERITY IN HUMAN CANCER
A regular reaction of cancer medicine is bone marrow concealment. The resulting myelosuppression and iron deficiency can cause huge morbidity and mortality for patients. Mediators, for example granulocyte colony stimul...
AQUIRED IMMUNO DEFICIENCY SYNDROME AND ITS OPHTHALMIC MANIFESTATIONS. SHORT REVIEW ARTICLE.
Rising trend of HIV seropositivity in TB patients in India and involvement of multi organ system and multiple opportunistic infections in AIDS is quite worrying1-3. India is emerging globally as a country with the larges...
HELLP SYNDROME: A BRIEF REVIEW
HELLP is an abbreviation of hemolysis (H), elevated liver enzyme (EL), and low platelet count (LP) which is a serious complication in pregnancy and also described as a severe form of preeclampsia and which is also associ...
Therapeutic effect of quercetin on the complications of nicotinamide-streptozotocin induced type-2 diabetes in male rats
Introduction: Type-2 diabetes mellitus (T2DM) is a rapid growing epidemic disease, with a continually increasing prevalence that exhibit complications in different body organs. The nicotinamide-streptozotocin (NA-STZ) ra...
To Study the Mechanisms of Granule Formation in the Wet Granulation Process
Traditionally wet agglomeration processes have been considered an empirical art, with great difficulties in predicting and explaining observed behavior. Industry has faced a range of problems including poor product quali...