Comparative Acute Oral Toxicity Study of Verona Anti-BPH with Verona Max in Mice
Journal Title: RADS Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 6, Issue 4
Abstract
Objective: Benign Prostate hyperplasia (BPH) is hyperplasia of prostate gland and age related diseases in men. 20%-60% men have BPH with the age of 40 to 60 years. The cause is not very well researched however the pharmacological and surgical current treatments have numerous toxic effects on quality of life. Natural medicines are known for its safety as compare to pharmacological choice of medicines. By considering this fact, current experimental study was established to compare and assess the acute oral toxicity of the Verona Anti-PBH with Verona Max in NMRI strain of mice on animal model. Methodology: NMRI mice were obtained for experimental purpose from animal house facility of Herbion Pvt. Ltd. Constant environmental conditions were 25 ± 1 °C with R.H 52 - 61% with 12 hours dark and light cycle. As per desire, food and water were available. Animals were divided into three different groups including two treatment and control group. Treatment group including Verona Anti-BPH and Verona Max however control group were on water. Animal’s age were 6-8 weeks and average body weight were 25-35 g however cage cards were used for identifications between the groups. Mice were treated orally using gastric gavage with doses (1 or 5g/kg) of test product for 14 days and observed daily. Results: The Verona anti-BPH and Verona Max did not cause any sign of ill health and acute toxicity in mice at the given doses of 1 or 5 g/kg. No hair loss, color loss, heart rate (chest expansion and retraction), writhing, stretching and fecal abnormality was observed. No remarkable change in the behavior and no mortality was observed. Conclusion: The present study evaluated that Verona anti-BPH and Verona Max extract is potentially safe and no acute oral toxicity has found.
Authors and Affiliations
Hina Rehman
Keywords
Related Articles
- EP ID EP605047
- DOI -
- Views 202
- Downloads 0
Acute and Sub Chronic Oral Toxicity Studies of Weight Loss Formulation in Experimental Animal Models
Objective: The current preclinical study aimed at appraising the claim of safety of the polyherbal weight reducing tablet formulation by evaluating its acute and sub chronic oral toxicity. Methodology: The acute oral to...
JUW IN THE FORE FRONT OF JOURNALISM
Jinnah University for Women, Karachi, Pakistan has the distinction to initiate and start three journals under the umbrella of Rayazuddin Research & Development Society. These three journals are Journal of Pharmacy and Ph...
Review on Pharmacological Activities and Homeopathic Uses of Eucalyptus globulus
Medicinal plants are very important from very ancient times to treat the ailments. It is the oldest method of treatment and becomes very popular especially in developing countries. Eucalyptus an evergreen plant belonging...
Prescribing Practices of Broad Spectrum Antibiotics in Tertiary Care Hospital: An Observational Study
Objective: The present study was designed to investigate the utilization of broad spectrum antibiotics in a tertiary care hospital setup. Methods: The observational study was evaluated 685 in-patients admitted in variou...
Utilization of Essential Oil in Manufacturing of Different Types of Balm
Background:Despite of great improvements and advancements in the amenities of life, alternative medicine’s trends is increasing day by day. It is obvious that all plants are significantly potent as well as effective with...