Comparative Assessment of the Effectiveness and Safety of Sertaconazole Cream Versus Terbinafine Cream Versus Luiliconazole Versus Clotrimazolecream in Patients with Tineacruris
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Dermatophytosis is an infection of keratinized tissues, epidermis and its appendages hair and nails.Topical treatment of dermatophytosis has advantages like targeting the site of infection which minimizes systemic side effects, and enhanced efficacy of treatment. Topical therapy is also considered to improve patient compliance. So to assess the effectiveness and safety of sertaconazole cream versus terbinafine Cream versus luiliconazole versus clotrimazolecream in patients with a form of dermatophytosis i.e.tineacruris (dermatophytosis of groin and adjacent areas). Material and Method: A randomized, open-label, cohort study was performed over a period of 18 months, from January 2014 to June 2015. Results: The study was continued till 30 participants in each group were available for analysis; a study population of 120 participants was achieved. Age group obtained in this study was indeed ranged from 18 years to 50 years. There were 64 (53.3%) males and 56 (46.7%) female participants in this study. The participants were randomized into four study groups: (A) Sertaconazole, (B) Luliconazole, (C) Terbinafine, (D) Clotrimazole. Conclusion: Response to the topical monotherapy with and sertaconazole 2%, luliconazole 1%, terbinafine 1% and clotrimazole 1% cream was safe and well tolerated in the treatment of tineacruris. Treatment with sertaconazole 2% cream and luliconazole 1% cream was early in the onset with tolerable side-effects.
Authors and Affiliations
Sanjay Khare, Rahul Nagar, Burhanuddin Saify
Keywords
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