Comparative Clinical Study of the Effectiveness of MEKRITEN in Patients with Chronic Suppurative Otitis

Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2018, Vol 15, Issue 2

Abstract

Objectives: Chronic suppurative otitis media (CSOM) is a serious disease with the presence of bacterial infection in the middle ear. Worldwide, 1% to 46% of the population living in developed and developing countries have CSOM, about 65-330 million people, 60% of whom have significant hearing loss. The study of the wound healing efficacy and tolerability of the drug MEKRITEN (garlic extract liquid) was performed to identify the possibility of issuing recommendations for the drug for clinical use in the Republic of Uzbekistan. Materials and Methods: The main group of patients, who received the study drug, consisted of 30 patients; the group of patients who received the comparison drug comprised 20 patients. Patients of the main group (30 persons) were given ‘garlic extract liquid,’ which was developed by the Tashkent Pharmaceutical Institute, given as 2 drops twice per day for 10 days in the external auditory canal. Patients in the comparison group (20 people) took other drugs (0.25% solution of levomycetin) in a similar way. Patients were examined and observed carefully to determine the severity of symptoms such as pain, secretion (in points), and clinical analyses were performed including general blood analysis, and urine. In addition, the researchers performed biochemical (ALT, AST, bilirubin), instrumental (ultrasound of the liver), and special (biopsy of fibrous tissue of echinococcal capsules) analyses. Results: The average rating of the tolerability and effectiveness in the points for MEKRITEN made portability of 4.97 points, and the effectiveness was 4.77 points, and for 0.25% levomycetin solution, they were 4.8 and 3.35 points, respectively. While receiving MEKRITEN, no adverse effects and allergic reactions were observed. No criteria for treatment cessation were observed (adverse effects, ineffective treatment, poor adherence to protocol, and refusal to continue) thus the study was not stopped in any patients. Conclusion: Local therapy with the drug MEKRITEN in patients with CSOM is more effective than local application of 0.25% levomycetin solution. Local therapy with MEKRITEN in the treatment of CSOM leads to faster termination of otorrhoea and is accompanied by fewer adverse drug reactions.

Authors and Affiliations

Abror MUKHITDINOV, Nemat OLIMOV, Shirinkhan OLIMOVA

Keywords

Related Articles

Activation of Two Different Drugs Used in Alzheimer’s Disease Treatment on Human Carbonic Anhydrase Isozymes I and II Activity: an In Vitro Study

Objectives: Human carbonic anhydrase I and II (hCAI, II) isoenzymes were purified from human erythrocyte. Kinetic interactions between the enzymes and memantine and donepezil, two different drugs used in Alzheimer’s dis...

Optimization of Immobilized Aldose Reductase Isolated from Bovine Liver

Objectives: Isolation of enzymes and experiments on them require great effort and cost and are time-consuming. Therefore, it is important to extend the usability of the enzymes by immobilizing them. In this study our pur...

Design and In Vitro Evaluation of Eudragit-Based Extended Release Diltiazem Microspheres for Once- and Twice-Daily Administration: The Effect of Coating on Drug Release Behavior

Objectives: The aim of this investigation was to develop an extended release formulation of diltiazem hydrochloride (DL) for once- and twice-daily administration, based on Eudragit (Eud) RL and RS microspheres using emul...

Evaluation of the Antidiabetic Activity of Alchemilla persica Rothm. in Mice with Diabetes Induced by Alloxan

Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica, belonging to this genus, is widely distributed in Eastern Anatolia as well a...

Antiplasmodial Activity of the n-Hexane Extract from Pleurotus ostreatus (Jacq. ex. Fr) P. Kumm.

Objectives: Several mushrooms species have been reported to be nematophagous and antiprotozoan. This study reported the antiplasmodial and cytotoxic properties of the n-hexane extract from the edible mushroom Pleurotus o...

Download PDF file
  • EP ID EP382470
  • DOI 10.4274/tjps.52824
  • Views 135
  • Downloads 0

How To Cite

Abror MUKHITDINOV, Nemat OLIMOV, Shirinkhan OLIMOVA (2018). Comparative Clinical Study of the Effectiveness of MEKRITEN in Patients with Chronic Suppurative Otitis. Turkish Journal of Pharmaceutical Sciences, 15(2), 184-189. https://www.europub.co.uk/articles/-A-382470