Comparative cytogenetic mapping of the HSPB1 locus in the genomes of Bovidae
Journal Title: Journal of Animal Science, Biology and Bioeconomy - Year 2015, Vol 33, Issue 3
Abstract
The HSPB1 protein, from the family of small heat shock proteins (sHsps), plays a functional role in the regulation of many intracellular processes and protection from environmental stress factors. Mutations of the HSPB1 gene are the reason for neuronal cells dysfunction associated with myopathies, motor neuropathies and neurodegenerative disorders, including prion diseases. Precise, chromosomal localization of this gene may contribute to the identification of new QTL correlated with resistance/susceptibility to prion diseases in Bovidae. As a result of comparative mapping performed by FISH technique with species-specific and heterologous molecular probes the location of HSPB1 gene was assigned to 25q22 cattle and goat genome region as well as sheep 24q22. Physical localization of the HSPB1 gene in the genomes of the studied species assigned its attachment to the linkage and syntenic groups of genes, which is essential for the expectation of the genetic selection effects.
Authors and Affiliations
Barbara Danielak-Czech, Anna Kozubska-Sobocińska, Marek Babicz
Keywords
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