Comparative Effects of Glibenclamide and Metformin on C-Reactive Protein and Oxidant/Antioxidant Status in Patients with Type II Diabetes Mellitus
Journal Title: Sultan Qaboos University Medical Journal - Year 2012, Vol 12, Issue 1
Abstract
Objectives: Tis study aimed to compare the effects of metformin and glibenclamide on high sensitivity serum C-reactive protein (hs-CRP) and oxidative stress, represented by serum malondialdehyde (MDA) and total antioxidant status (TAS) in newly-diagnosed patients with Type 2 diabetes mellitus (DM) at baseline and after 2 months of therapy in comparison to controls. Methods: Te subjects, recruited from Al-Wafaa Centre for Diabetes Management and Research, Iraq, November 2009 to January 2011, were 103 newly-diagnosed Type 2 DM patients; 53 were prescribed metformin and 50 glibenclamide. Te control group was 40 apparently healthy volunteers. Blood samples were taken from all subjects after overnight fasting. Sera were separated and assays of hs-CRP, MDA and TAS were done. After 2 months monotherapy, the blood samples and assays were repeated. Results: Tere were signifcant differences between patients prescribed metformin and glibenclamide and the controls with regard to serum hs-CRP, MDA and TAS. Tere was a signifcant reduction in the serum MDA and a signifcant raise in the serum TAS levels, with no signifcant effects on serum hs-CRP levels after metformin therapy, but no signifcant effects on these parameters after glibenclamide therapy. Te percentage of variation in these parameters after both drugs, showed a signifcant raise in serum TAS levels with the metformin therapy with no signifcant effects in serum MDA and hs-CRP. Conclusion: Metformin positively affected the oxidant/antioxidant balance in newlydiagnosed Type 2 DM patients with no signifcant effects on acute phase reaction protein. Glibenclamide had no signifcant effects on oxidant/antioxidant balance and acute phase reaction protein.
Authors and Affiliations
Alaa A. A. Abdulkadir| Department of Clinical Pharmacy, College of Pharmacy, University of Mosul, Mosul, Iraq, Imad A-J. Tanoon| Department of Pharmacology, College of Medicine, University of Mosul, Mosul, Iraq
Keywords
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