Comparative efficacy of mono- and combined therapy for idiopathic short stature with delayed puberty
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 3
Abstract
Background. Growth hormone therapy for idiopathic short stature (ISS) is a subject of debate, because of the heterogeneous endocrine profile in these children. The purpose of this work was to evaluate the effectiveness of mono- (testosterone enanthate) and combined therapy (testosterone enanthate and recombinant growth hormone) in adolescents with idiopathic short stature. Materials and methods. The examined youths of Uzbek population (n = 46) with constitutional delay in growth and puberty aged 14.8–16.2 years were divided into three groups in accordance with the type of treatment. Results. It was found that recombinant growth hormone (somatropin) therapy (0.033 mg/kg/day) in combination with testosterone enanthate (50 mg once every 21 days) is effective and increases the rate of growth in idiopathic short stature with delayed puberty. Conclusions. Monotherapy with testosterone enanthate at a low dose significantly increases the rate of growth in boys with constitutional delay in growth and puberty, compared with the group without treatment, but is significantly less effective than in the group of combined therapy.
Authors and Affiliations
G. N. Rakhimova, K. N. Gilyazetdinov
New Opportunities for Diabetes Mellitus Treatment
The paper presents the results of the study of the efficiency and safety of the insulins Insuman® Rapid, Insuman® Basal, Insuman® Comb 25 in patients with type 2 diabetes mellitus. Those medications were found to have hi...
Reproductive Function Disorders in Women with Thyroid Dysfunction (Review of the Problem)
The article provides the information on the prevalence in the population and the impact on female reproductive function of diseases associated with thyroid hypofunction. The authors analyzed the literature on this issue....
Morphological Changes of Pulmonary Bloodstream in Type 2 Diabetic Patients
The pathomorphological investigation of pulmonary vessels found the changes being developed in diabetic microangiopathy in other organs and affecting firstly the morphological structures responsive for respiratory exchan...
Effect of Pro197Leu Polymorphism of the Gene GPX1 on Carbohydrate Metabolism and Anthropometric Indices of Patients with Arterial Hypertension Against the Background of Abdominal Obesity
The aim of our study was to investigate the dependence of carbohydrate metabolism in patients with arterial hypertension and concomitant abdominal obesity depending on Pro197Leu polymorphism of the GPX1 gene. Pro197Leu p...
Current Therapy of Type 2 Diabetes Mellitus using a Sample of SulfonylureaG — Prolonged Releasing Gliclazide Produced by Pharmak, Ltd (Kyiv, Ukraine)
The paper describes the efficacy of sulfonylurea derivative — domestic medication Dіaglizide MR (Farmak, Ltd) in the treatment of type 2 diabetes mellitus. The efficacy and safety of the agent confirmed in scientific stu...