Comparative evaluation of blood culture, estimation of immunoglobulin m (igm) and c-reactive protein (crp) detection in the diagnosis of neonatal sepsis
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2014, Vol 6, Issue 2
Abstract
This clinical study was conducted to evaluate the diagnostic value of C-reactive protein (CRP), Immunoglobulin M (IgM) in the early diagnosis of neonatal sepsis. The diagnostic values of each marker separately or in combination were evaluated. Blood culture, IgM and CRP estimation were performed on 50 clinically suspected to have septicemia. Blood culture positive were seen in 54.0% cases with predominant organism being Klebsiella pneumoniae (47.8%) and among Gram positive Staphylococcus aureus (13.1%). IgM level >20mg/dl (cut off value) was found in 46.0%cases and CRP level >5mg/dl (cut off value) was seen in 52.0% of culture proven sepsis. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CRP versus blood culture were 91.30, 81.40, 80.77 and 91.67 respectively, IgM versus blood culture were 86.90, 88.89, 86.96 and 88.89 respectively and combined IgM & CRP versus blood culture were 95.65, 81.48, 81.41 and 96.65 respectively. CRP is a single useful marker with high sensitivity and IgM with high specificity in predicting neonatal sepsis. Combination of these tests showed higher sensitivity and negative predictive value when compared to CRP and IgM estimation alone in diagnosing septicemia. CRP and IgM in combination sensitivity increased from 91.30%-95.65% and can be used as better predictor of neonatal infection and helpful in predicting neonatal sepsis while awaiting for culture report. We speculate a significant role of this combination in making decisions regarding antibiotics treatment and upgrading the level of medical care.
Authors and Affiliations
Kamble Arati Nagarathnamma T. ,, Asha Benakappa
Keywords
Related Articles
- EP ID EP406022
- DOI -
- Views 154
- Downloads 0
Antibiotic susceptibility and presence of virulence genes in arcobacter butzleri strains isolated from poultry, costa rica
Arcobacter butzleri, is an emerging potential foodborne zoonotic pathogenthat has been classified as a serious hazard for human health by the International Commission on Microbiological Specifications for Foods (ICMSF)....
Prevalence of dental caries among school children in Chennai
Background: Dental caries is highly prevalent and a significant public health problem among children throughout the world. The prevalence and incidence of dental caries in a population is influenced by a number of risk f...
A comparative study of physiological cost index in cp and normal children on two different surfaces
To compare energy expenditure of ambulation on even indoor and uneven outdoor surface in CP children as well as between CP and asymptomatic children. Objective: To find out and compare physiological cost index on even i...
Correlation between HBV DNA levels, HBeAg and Liver function tests in untreated Chronic Hepatitis B patients
Chronic hepatitis B is a condition where various prognostic markers guide in therapy with antiviral agents. In this study we identified all the untreated chronic hepatitis ‘B’ patients, quantified hepatitis B virus DNA i...
Effects of ascorbic acid supplementation on the haematological status of teenage pregnant women in Ibadan, Nigeria
The effect of supplementing a regular diet with ascorbic acid on haematological indices was studied in teenage pregnant women attending antenatal clinics of three government hospitals in Ibadan, Nigeria. Informed consent...