COMPARATIVE IN VITRO ANALYSIS OF PHYSICOCHEMICAL PROPERTIES OF SOME ACECLOFENAC GENERIC TABLETS MARKETED IN BANGLADESH
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 3
Abstract
Aceclofenac is a non-steroidal anti-inflammatory drug analog of diclofenac and works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandin (PG) and accountable for pain, swelling, inflammation, and fever. Present study was targeted to assess various physicochemical parameters of aceclofenac tablets marketed in Bangladesh by different manufacturers using in vitro quality control tests. Brand products tested in our study had acceptable hardness, average weight, friability, disintegration and potency. All the brands released more than 80% of drug in the first 30 minutes except for brand A9. The dissolution profiles were compared utilizing difference factor (f1) and similarity factor (f2) which showed that all the brands except A6 are similar with brand A3 and can be used in exchange for A6. Keywords: Aceclofenac, NSAID, dissolution, disintegration, difference factor, similarity factor.
Authors and Affiliations
Kaniz Afroz Tanni
Keywords
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