COMPARATIVE IN-VITRO BIOAVAILABILITY STUDIES ON DIFFERENT BRANDS OF BACLOFEN TABLET AVAILABLE ON BANGLADESH MARKET
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 7
Abstract
The presence of numerous generic brands of Baclofen in the local drug market makes the situation difficult for health professionals and patients to choose the appropriate product. This study was intended to evaluate the bioequivalence of three marketed brands of baclofen (10 mg) tablets from different manufacturers using in vitro dissolution study in order to minimize health risk factors. Drug releases were compared with that of a reference product. The dissolution profiles showed release of drug at 10, 20, 30 and 45 minutes time point. All the brands achieved 85% dissolution within 45 minutes. Test results were subjected to statistical analysis to compare the dissolution profile. Model independent approaches of difference factor (f1) and similarity factor (f2) were employed. Using a validated high performance liquid chromatography method, Other general quality parameters of these tablets like diameter, thickness, hardness, friability, weight variation, disintegration time were also evaluated and test results were within the limit.
Authors and Affiliations
Farzana Hasin
Keywords
Related Articles
- EP ID EP618286
- DOI -
- Views 182
- Downloads 0
REVIEW ON RUTA GRAVEOLENS
Bioassay-directed isolation of antifungal compounds from an ethyl acetate extract of Ruta graveolens leaves yielded two furanocoumarins, one quinoline alkaloid, and four quinolone alkaloids including a novel compound, 1-...
ACTIVE VERSUS EXPECTANT MANAGEMENT OF THIRD STAGE OF LABOUR
Background: Expectant management of the third stage of labour involves allowing the placenta to deliver spontaneously or ided by gravity or nipple stimulation while, active management involves administration of prophylac...
THE IMPACT OF HIV AND MALARIA CO-INFECTION ON CARDIAC BIOMARKERS AND CD4+ T CELL COUNTS IN ADULT HIV SEROPOSITIVES IN NAUTH NNEWI, SOUTH EASTERN, NIGERIA.
Aim: To determine the impact of HIV and malaria co-infections on Cardiac biomarkers and CD4+ T cell counts in adult HIV seropositives in NAUTH Nnewi, South Eastern, Nigeria. Methods: A total of 400 subjects aged between...
THE ANTIBACTERIAL EFFECT OF FLAXSEED EXTRACT ON SELECTIVE ORAL PATHOGENS - COMPARATIVE IN VITRO STUDY
Introduction: Flaxseed from the flax plant (Linum usitatissimum), which has been cultivated for domestic use since prehistoric times. This study aims to investigate presence of antibacterial effect of flaxseed extract ag...
EVALUATION OF THE INTERACTION OF THREE TYPES OF ANTRACICLINES AND NEUROTRASMISORS USING QUANTIC CHEMICAL SIMULATION
In this work we analyze three types of anthracyclines (ACys). The analysis consists of observing how these ACys interact with the neurotransmitters (NT). These drugs are used in the treatment of different types of cancer...