COMPARATIVE STUDIES OF EFFICACY AND EFFECTS ON OXIDATIVE STRESS OF AMLODIPINE AND RAMIPRIL IN THE HYPERTENSIVE PATIENTS OF NORTH EAST INDIA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 12
Abstract
Objective: To compare the efficacy and the effect of the oxidative stress of Calcium Channel Blocker (CCB), Amlodipine and Angiotensin Converting Enzyme (ACE) inhibitor, Ramipril in the hypertensive patients of North East India.Methods: It is a prospective randomized controlled parallel study of the clinically used antihypertensive drug. Total 75 subjects were included in the study. Out of 75 subjects, 25 numbers were normal healthy subjects and remaining 50 were hypertensive patients. The patients were randomized and divided into two groups; Amlodipine treated group (n=25) and Ramipril treated group (n=25). Amlodipine group received Amlodipine (5-10) mg/day and Ramipril group received Ramipril daily (5-10) mg. All patients were newly detected hypertensive subjects suffering from essential hypertension without any prior antihypertensive therapy. Patients included were either sex (male/female) in age group of 20-65 y with normal fasting blood sugar level (FBS) and free from any other diseases. All groups was subjected to measurement of blood pressure, estimation of blood parameters like FBS, serum lipid profiles, serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate (SGOT) before antihypertensive treatment. The height, age, weight, health status and lifestyle pattern of patients were recorded. The patients were followed up during 8 w of antihypertensive treatment. Serum levels of glutathione (GSH), total antioxidant (TAS), superoxide dismutase (SOD) and malondialdehyde (MDA) levels were estimated before and after 8 w of antihypertensive therapy.Results: The present study indicated that both amlodipine and ramipril have significant effects on normalizing systolic and diastolic blood pressure (BP) after 8 w of treatment. Ramipril significantly reduced malondialdehyde (MDA) level and increased the serum levels of GSH, TAS and SOD during antihypertensive treatment. Ramipril reduces oxidative stress because of its antioxidant activity during antihypertensive therapy.Conclusion: Amlodipine and Ramipril are effective antihypertensive drugs. ACE inhibitor (Ramipril) has additional benefit of reducing oxidative stress thereby restoring the endothelial dysfunction in the hypertensive patient.Â
Authors and Affiliations
Surajit Tamuli, Sanjeev Kakati, Sanjib Das, Khumanthem Deepak Singh, Surajit Kumar Ghosh
Keywords
Related Articles
- EP ID EP578043
- DOI -
- Views 79
- Downloads 0
STUDY OF ENHANCED ANTI-INFLAMMATORY POTENTIAL OF NIGELLA SATIVA IN TOPICAL NANOFORMULATION
Objective: Formulate a nanocarrier for enhancing the anti-inflammatory activity of thymoquinone (Tq), a major active constituent of Nigella sativa.Methods: Nanoformulation of Tq was developed by low energy emulsification...
RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN, RAMIPRIL, HYDROCHLOROTHIAZIDE, SIMVASTATIN AND ATENOLOL FROM PHARMACEUTICAL DOSAGE FORM
Objective: The present study was designed with an objective of a simple, fast, precise, selective and accurate RP-HPLC method was developed and validated for the simultaneous determination of Aspirin, Ramipril, Hydrochlo...
ASSESSMENT OF KIDNEY FUNCTION, ESTIMATED GLOMERULAR FILTRATION RATE AND BODY MASS INDEX IN HIV SEROPOSITIVE SUBJECTS ON ANTIRETROVIRAL THERAPY IN NNEWI
Objective: Antiretroviral therapy (ART) is anticipated to result in an increase in long-term survival in human immunodeficiency virus (HIV) infected individuals, but may present with the development of associated complic...
CHARACTERIZATION OF DIFFERENT SYZYGIUM CUMINI SKEELS ACCESSIONS BASED ON PHYSICO-CHEMICAL ATTRIBUTES AND PHYTOCHEMICAL INVESTIGATIONS
Objective: To study variability in respect to physico-chemical and phytochemical characteristics of fruits.Methods: The twelve accessions with uniform growth and vigour were selected to study physico-chemical characteris...
PROTECTIVE EFFECT OF MELATONIN AGAINST IRON OVERLOAD-INDUCED TOXICITY IN RATS
Objective: Iron overload is a serious, potentially fatal disorder characterized by the deposition of excess iron within tissues leading to functional impairment and reduced life expectancy. The present study was designed...