COMPARATIVE STUDY BETWEEN INTRAVENOUS DEXAMETHASONE VERSUS KETAMINE GARGLE VERSUS INTRAVENOUS DEXAMETHASONE COMBINED WITH KETAMINE GARGLE FOR EVALUATION OF POST-OPERATIVE SORE THROAT AND HOARSENESS IN MIDDLE EAR SURGERY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 13
Abstract
BACKGROUND Endotracheal intubation is the common cause of trauma to the airway mucosa, resulting in post-operative sore throat (POST) and hoarseness. This study was done to evaluate and compare the effectiveness of prophylactically used dexamethasone-ketamine combination compared with IV dexamethasone/ ketamine-gargle alone in POST and hoarseness in patients undergoing elective middle ear surgery receiving general anaesthesia with endotracheal intubation. MATERIALS AND METHODS This was a prospective, randomised, placebo-controlled and double-blinded clinical study, in which 80 patients (as per convenience as there are 4 groups in my study and availability of patients who meet with the study criteria) aged (16 - 45 yrs.). ASA grade I and II were posted for middle-ear surgery. They were randomly assigned with informed consent into 4 groups (n= 20); Group K: gargled 40 mg ketamine in 30 mL NS for 30 sec; Group D: gargled 30 mL normal saline for 30 sec, received 0.2 mg/kg IV dexamethasone, Group KD: gargled 40 mg ketamine in 30 mL NS for 30 sec and received 0.2 mg/kg IV dexamethasone and Group P: gargled 3 mL NS for 30s, received IV NS (all measures were done 5 mins before induction. POST and hoarseness were graded post-operatively at 0, 1, 6, 12 and 24 hrs.). RESULTS The incidence and severity of POST were significantly lower in Group KD compared with other groups at all times during 24 hrs. post-operatively. Also, the incidence and severity of hoarseness were significantly lower in each one of Groups of KD, K and D compared with Group P. But no significant differences between Groups KD with Group K and Group D. Most of the patients of Group P suffered from POST and hoarseness. CONCLUSION For reducing incidence and severity of POST and hoarseness, administration of ketamine-gargle combined with IV dexamethasone was more effective than using each of these drugs alone at all times after extubation
Authors and Affiliations
Surendra K. Raikwar, Rajkumar Ahirwal, Sweety Bhola
Keywords
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- EP ID EP412243
- DOI 10.14260/jemds/2018/370
- Views 92
- Downloads 0
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