Comparative Study between Quaternary Ammonium Compounds and Formalin in Clean Room Sanitation
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Sanitization of Pharmaceutical clean room is always been a burning issue for clean room experts. This is not only because of the sensitivity of product manufactured in clean room but also due to emergence of natural resistance of Micro-organisms , regulatory requirement ,which are becoming strict day by day and the effect of chemicals used for the disinfection of clean on human health. Today there is a very vast range of chemicals available for clean room sanitation and each of them has its own disadvantages and advantages. Formaldehyde and Quaternary ammonium compound are being used for clean room sanitation. A comparative study was conducted between these two compounds to find out advantages and disadvantages of these two chemicals. For this purpose a clean room facility was selected which was classified as “Grade B” and Grade “C”. These Grades are the filtration grades classified by World Health Organization for the aseptic processing of Parenteral products. Grade B is very high risk area as the operator standing in this grade throughout the batch processing and doing all activities. According to the USP, the biggest source of microbial contamination is a man. A simulation batch processing activity was carried out and then the area was de-contaminated with Quaternary ammonium compound. Samples were collected after area decontamination. Again another simulation batch processing activity was performed and this time area was decontaminated with Formalin (Formaldehyde). Samples were collected after decontamination and the results of both (Formaldehyde and Quaternary ammonium compound) were compared.The results shows that the Quaternary ammonium compound are much better than formaldehyde and have less health effect on human.
Authors and Affiliations
M. Nadeem Javed Qureshi, Dr. Kashif A. Safdar, W. Jamil3, Dr. Jawaid A.
Keywords
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