COMPARATIVE STUDY OF HAEMODYNAMIC CHANGES DURING INDUCTION OF GENERAL ANAESTHESIA: PROPOFOL VERSUS ETOMIDATE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 27
Abstract
BACKGROUND Induction of general anaesthesia is a critical part of anaesthesia practice. An ideal inducing agent for general anaesthesia should have haemodynamic stability, minimal respiratory side effects and rapid clearance. Sudden bronchospasm, hypotension, arrhythmias, respiratory depression and cardiovascular collapse are life threatening complications following induction. It is desirable to use a safe agent with fewer adverse effects for this purpose. We wanted to compare the haemodynamic responses while inducing with intravenous propofol versus etomidate utilizing the standard methods for the drugs. METHODS An ideal induction agent for general anaesthesia should have haemodynamic stability, minimal respiratory side effects and rapid clearance. Presently there are a number of induction agents available. Thiopental is the conventional induction agent discovered in 1934 by John S. Lundy, known for rapid action and rapid awakening,1 has an additional property of decreasing ICP in refractory cases. Studies have showed that it causes peripheral vasodilatation, decrease in blood pressure, increase in heart rate and has direct negative ionotropic effect on heart. RESULTS The responses measured were heart rate, blood pressure, diastolic blood pressure and MAP. In our study, we found that, patients who received etomidate, when compared to propofol group, were haemodynamically stable during and 10 minutes post induction and intubation. CONCLUSIONS Etomidate provides better haemodynamic stability during induction than propofol, in patients undergoing surgeries, under general anaesthesia with endotracheal intubation.
Authors and Affiliations
Krishnanakutty Saradas Asha, Manohar Neethu
Keywords
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- EP ID EP668562
- DOI 10.18410/jebmh/2019/373
- Views 99
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