Comparative study of hemodynamic profile in intraoperative period and side effects of epidural ropivacaine with clonidine and dexmedetomidine for lower limb surgeries
Journal Title: International Journal of Medical Science and Public Health - Year 2015, Vol 4, Issue 5
Abstract
Background: Epidural anesthesia gained great popularity by virtue of its distinct advantages over spinal anesthesia, such as provision of extended anesthesia in prolonged surgeries; early ambulation of patients, which reduces the hospital stay; and reduced incidence of postsurgical complications such as deep vein thrombosis. Objective: To study ropivacaine with clonidine and dexmedetomidine in epidural anesthesia for lower limb surgeries with respect to hemodynamic profile in intraoperative period and their side effects. Materials and Methods: Sixty patients of either sex of ASA grades I and II aged between 20 and 60 years were included in the study and randomly divided in two groups: group RC, patient received ropivacaine (0.75% 20 mL) with clonidine (2 μ g/kg; n = 30); group RD, patient received ropivacaine (0.75% 20 mL) with dexmedetomidine (1.5 μ g/kg; n = 30). The hemodynamic param - eters recorded were mean heart rate, mean systolic blood pressure, mean diastolic blood pressure (DBP), and mean arterial pressure (MAP), respiratory rate, and oxygen saturation. These parameters were recorded preoperatively and then at 5-min intervals during intraoperative period till the end of the surgery. The study was carried out in the Department of Anesthesia, Grant Medical College Hospital, Indore, Madhya Pradesh, and Sir J.J. Group of Hospitals, Mumbai, Maharashtra, India. Results: Heart rate was lower in group RD compared with group RC from 10 to 40 min intraoperatively, although it remained stable throughout the intraoperative period in both the groups. DBP was lower in group RD compared with group RC from 15 to 20 min intraoperatively. MAP was lower in group RD compared with group RC from 10 to 20 min intraoperatively, although it remained stable throughout the intraoperative period in both the groups. Oxygen saturation and respiratory rate showed no statistically significant differences and remained stable throughout the intraoperative period in both the groups. The incidence of side effects such as nausea, vomiting, dizziness, headache, and respiratory depression was nil in both the groups, while the incidence of dry mouth in both the groups was equal 36.33%, and the difference was not significant. Conclusion: Hemodynamic parameters such as heart rate, blood pressure, oxygen saturation, and respiratory rate remained stable throughout the intraoperative period with both dexmedetomidine and clonidine.
Authors and Affiliations
Shrikrishna Bamne, Shrirang Bamne, Avantika Bamne
Keywords
Related Articles
- EP ID EP127725
- DOI 10.5455/ijmsph.2015.04122014126
- Views 120
- Downloads 0
A cross-sectional study of gender preference among married urban women of Central India
Background: Despite the existing preconception and prenatal diagnostic technique act, there is a strong preference for males in societies. There is a need to strengthen the law and to address various social reasons for m...
Effect of gestational age on pulmonary functions in pregnant Odia women
Background: Pregnancy is a physiological state of adaptation that results in significant hormonal, mechanical and cardiorespiratory changes. Progesterone increases minute ventilation. In Odisha, where malari...
Serum uric acid in metabolic syndrome
Background: The metabolic syndrome consists of a constellation of metabolic abnormalities including central obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, hyperglycemia and hyperten...
Age at natural menopause and factors affecting menopausal age: A cross-sectional study among postmenopausal female attendees of obstetrics and gynecology outpatient department
Background: Menopause has now become a predominant subject of study as the life expectancy is globally on an increase. The average life expectancy at birth for females in India is 69.9 years. The average age at menopause...
Prevalence of maternal anemia and its impact on perinatal outcome in a rural area of Dakshina Kannada
Background: The prevalence of anemia among pregnant women averages 56%, ranging between 35% and 100% among different regions of the world. It is now one of the most frequently observed nutritional diseases in the world....