Comparative study of oral versus vaginal misoprostol for cervical ripening in gynaecological procedures
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Office hysteroscopy and endometrial aspiration are the most common investigations in patients presenting with infertility or abnormal vaginal bleeding. Difficulty in cervical dilatation during these procedures may cause excessive pain, cervical tear or uterine perforation. These complications can be reduced by using a cervical priming agent like misoprostol prior to the procedure. In this study, Two hundred nonpregnant patients undergoing gynaecological procedure were randomized to oral or vaginal misoprostol groups. 400 µg misoprostol was administered 3 hours prior to procedure in each group. After 3 hours cervical dilatation, pain perceived (VAS score), side effects of misoprostol or complication of the procedure were noted. Further comparison were made between nulliparous versus multiparous women and premenopausal versus postmenopausal women.The difference in mean cervical dilatation between the two groups was not found to be statistically significant. Mean VAS score during the procedure was comparable between both the groups. Sideeffects of misoprostol were seen more frequently in oral misoprostol group as compared to vaginal misoprostol group. Both oral and vaginal misoprostol were found to cause more cervical dilatation in multiparous women as compared to nulliparous women and in premenopausal women as compared to postmenopausal women.We conclude that misoprostol is effective in cervical ripening in non-pregnant women prior to gynaecological procedures. Both oral and vaginal route have similar efficacy. Side-effects are more common with oral route. Vaginal administration of misoprostol may be preferred prior to gynaecological procedures as it has minimal side-effects.
Authors and Affiliations
Dr Megha Punetha, DrDaya Sirohiwal
Keywords
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- EP ID EP370580
- DOI 10.9790/0853-1704060105
- Views 78
- Downloads 0
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