COMPARATIVE STUDY OF SPAN 40 AND SPAN 60 BASED SOY-GELS FOR TOPICAL DRUG DELIVERY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objective: Hydrogels or emulgels are recommended for topical application to elicit a local effect. However, they suffer from stability problems. The present study deals with the formulation and comparison of thermally stable soybean oil-based novel topical organogels (soy-gels) using two different gelators (Span 40 and Span 60) for controlled drug delivery. Methods: Soy-gels (8 batches) were developed with Span 40 and Span 60 by solid fiber mechanism and characterized for viscosity, gelation kinetics behavior, gel-sol transition parameters, drug content, in vitro drug release pattern, and changes occurring during accelerated thermal stability studies. Results: Fourier transformed infrared spectroscopic confirmed the compatibility among the organogel components and paracetamol. The formulations exhibited skin and hemocompatibility. The viscosity of Span 60 based soy-gels was found to be approximately 10 times higher than those of Span 40 based formulations. In comparison to Span 40, Span 60 induced faster gelation (3–6 min) of soybean oil at lower concentration (16% w/v) forming less flexible but thermally more stable soy-gels demonstrating higher Tg values. Higher flexibility and lower viscosity accounted for improved drug diffusion (both Fickian and non-Fickian) from Span 40 gels of varying concentrations in pH 5.8. However, zero-order drug release was observed in organogel with 18% w/v Span 40 only and all Span 60-based formulations except the one with 22% w/v Span 60. Non-Fickian drug diffusion occurred from Span 60 based soy-gels. A gradual increase in gelation time was observed until five cycles of freeze-thaw. Conclusion: Therefore, the choice of organogelator governs the rheological, thermal, and drug diffusion properties of soy-gels intended for topical application.
Authors and Affiliations
SHUBHAM MUKHERJEE , DIPANJANA ASH , GOPA ROY BISWAS , SUTAPA BISWAS MAJEE
Keywords
Related Articles
- EP ID EP608993
- DOI -
- Views 162
- Downloads 0
IN SILICO MODELING OF MONOMERIC DEXAMETHASONE-INDUCED RAS-RELATED PROTEIN 1 AND RAS HOMOLOG ENRICHED IN STRIATUM: ROLE OF N TERMINUS AND STRUCTURE‑FUNCTION RELATIONSHIP
Objective: Dexamethasone-induced Ras-related protein 1 (Dexras1) and Ras homolog enriched in striatum (RHES) are the two monomeric small G proteins that belong to Ras superfamily. These two proteins show 62% similarity....
EFFECT OF ANTI-BIOFILM POTENTIAL OF DIFFERENT MEDICINAL PLANTS: REVIEW
Medicinal plant products are the natural products which have been very useful for human to cure various ailments and as an alternative medicine for conventional therapy. However, bacteria in natural environments are main...
MANAGEMENT OF PSORIASIS: A FOCUS ON PHYTOCHEMICALS
Psoriasis is a hyperproliferative, autoimmune skin disorder. There are several therapeutic agents used topically and systemically, but they have adverse effects. It has been reported that beta-blockers intensify psoriati...
EFFECTS OF PHENOLIC COMPOUNDS EXTRACTED FROM SALVIA FRIGIDA ON INDUCED HYPERURICEMIA IN MICE
Objective: The aim of this study was to investigate effects of phenolic compounds rich fraction extracted from aerial parts of Salvia frigida on serum uric acid (SUA) and xanthine oxidase (XOD) in hyperuricemic mice mode...
EFFECTS OF ANTI ANXIETY DRUG MIDAZOLAM AS PRETREATMENT THERAPY FOR ANXIETY OF ZEBRA FISHES INDUCED BY THE EXPOSURE OF UNFAMILIAR ENVIRONMENT OF AQUATIC WHITE/BLACK MAZE
Objectves: The objective of our present research investigation was to evaluate the effectiveness of the aquatic white/black plus maze model toevaluate the efficacy of different treatment drugs on zebra fish behavior stud...