COMPARATIVE STUDY ON EFFECT OF SOLID DISPERSION TECHNIQUES FOR ENHANCEMENT OF DISSOLUTION RATE OF PIOGLITAZONE HCl
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
Pioglitazone hydrochloride is a novel antidiabetic drug in thiazolidinediones group and it improves insulin sensitivity in insulin resistant patients. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. The present study is an attempt to enhance the dissolution rate of pioglitazone HCl by kneading and physical mixture techniques using pioglitazone HCl and β-cyclodextrine as carrier in the ratios of 1:1, 1:2 and 1:3 respectively. The drug carrier interaction study was carried out by Fourier Transform Infrared Spectroscopy (FTIR). The prepared solid dispersions were characterized for percentage yield, bulk density, tapped density, Carr’s Index, Hausner’s ratio, angle of repose, drug content, drug dissolution and stability study. The FTIR study suggesting no interaction between drug and carrier of solid dispersion. The kneading and physical mixture techniques were found to be efficient method to obtained good yield solid dispersions with good flow properties. The drug content was found in the ranges of 77.2±0.28 to 88.8±0.19 %. Dissolution study revealed that there is marked enhancement in the dissolution rate of pioglitazone from all the solid dispersions when compared to pure pioglitazone itself. From the in vitro drug release profile, it can be seen that formulation F1 (1:1 ratio of drug: β-cyclodextrine, prepared by kneading technique) shows higher dissolution rate compared with other formulations. All pioglitazone solid dispersions were found to be stable in various storage temperatures. The kneading is suitable method for development of solid dispersion of pioglitazone HCl.
Authors and Affiliations
Sruti Mishra , Ellaiah P. , Prabhat Jena , Bhabani Nayak , Gitanjali Mishra
Keywords
Related Articles
- EP ID EP103285
- DOI -
- Views 160
- Downloads 0
A STUDY ON CO MORBIDITIES ASSOCIATED WITH PSORIASIS
Psoriasis is a chronic, disfiguring inflammatory and proliferative condition of the skin. The present study focused on the comorbidities associated with psoriasis patients and also the medications used for the treatment...
DETERMINATION OF PERMEATION PATHWAY OF GENTAMICIN INTO PIG’S EAR SKIN
Extensive research has been conducted in the recent years with a focus on drug administration via the skin for both topical and systemic drug delivery. Understanding the drug permeation through the skin is crucial for th...
SIMPLE UV SPECTROMETRIC FOR THE ESTIMATION OF METHOCARBAMOL IN BULK AND ITS FORMULATION
The objective of the work is to obtain a correct analytical method for analysis of active substance in bulk drug and in the finished product. From the literature survey, it was found that Methocarbamol used extensively i...
SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME TRIHYDRATE AND OFLOXACIN IN TABLETS
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of cefixime trihydrate and ofloxacin in combined tablet dosage form....
WORLD HEALTH ORGANIZATION’S GUIDELINES FOR BIOEQUIVALENCE STUDIES USING PHARMACOKINETIC MEASUREMENTS
The purpose of this study is to understand World Health Organization’s guidelines for Bioequivalence studies in humans. It is important for anyone preparing a trial of a medicinal product in humans that the specific aims...