Comparing gangion cell complex and retinal nerve fibre layer for the early diagnosis of glaucoma
Journal Title: World Journal of Pharmaceutical Sciences - Year 2018, Vol 6, Issue 11
Abstract
Context: With the newertechnologies like Optical Coherence Tomography(OCT), it’s time to rethink whether Retinal Nerve Fibre Layer (RNFL) thickness is the earliest tool for glaucoma detection or Ganglion Cell Complex (GCC) needs a reconsideration as we know that the cell bodies die prior to their processes. Purpose: To evaluate and compare the early glaucoma detection abilities of circumpapillary RNFL (cpRNFL) and macular GCC (mGCC) retrospectively on the OCT. Patients and Methods: 60 preperimetric glaucoma patients and 80 controls in an age group of 18-60 years were enrolled in this cross- sectional study. The cpRNFL thickness and mGCC of each patient were measured. Results: The Area under receiver operating characteristic curve (AUROC) curve was significantly higher for mGCC than that for cpRNFL. It was noted that the mGCC loss occurs prior to the decrease in the cpRNFL thickness. Conclusion: Prior studies have labelled GCC as just being complementary to RNFL in early detection of glaucoma but our study detected GCC to be superior. Thus the mGCC analysis though commonly performed needs recognition as an early detection tool for glaucoma.
Authors and Affiliations
Ashok H. Madan
Keywords
Related Articles
- EP ID EP506501
- DOI -
- Views 99
- Downloads 0
Recombinant DNA technology in drug discovery
Recombinant DNA (rDNA) technology has made a revolutionary impact in the area of human healthcare by enabling mass production of safe, pure and effective rDNA expression products. Constructing a recombinant DNA molecule...
Synthesis, characterization and identification of sertraline hydrochloride related impurities
Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, is synthesized for commercial use as a drug substance in highly pure form. During commercial production of Sertral...
Knowledge among final year student of pathological discharge in patients attending gynecology OPD
Women have so many medical problems due to the hormonal change with the age. Different abnormal discharges in women are common gynecological symptoms. Whilst most patients have benign disease, thorough investigation is n...
Quantitative analysis of α-glucosidase inhibitors by ECD with a column of the ion exchange resin of core-shell type filler
The α-glucosidase inhibitors, voglibose (VB), miglitol (MT), and acarbose (AB), are used as postprandial hyperglycemia inhibitors in the treatment of type 2 diabetes. The aim of this study was to develop a quantitative a...
Troubleshooting and maintenance of high-performance liquid chromatography- A Review
HPLC (High Performance Liquid Chromatography) has evolved into an indispensable tool in many analytical laboratories and is applied to diverse analytical problems. Troubleshooting HPLC instrumentation and separations req...