Comparison between palonosetron and ramosetron to prevent postoperative nausea and vomiting in patients undergoing laparoscopic surgery
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 3
Abstract
Introduction and Aims Postoperative nausea and vomiting PONV are very common and distressing adverse events after general anaesthesia Palonosetron and ramosetron are newer second generation selective 5HT3 receptor antagonists The present study was carried out to compare the efficacy and safety of palonosetron and ramosetron for prevention of postoperative nausea and vomiting PONV over the period of 72 hours in patients undergoing for laparoscopic surgery under general anaesthesiaMaterials and Methods 80 patients of ASA class I and II undergoing for various laparoscopic surgeries were randomly allocated into 2 groups of 40 each to receive Inj palonosetron 75 g group P or Inj Ramosetron 03 mg group R Patients were monitored for emesis severity of nausea requirement of rescue antiemetic and complete response up to 72 hours 06 624 2472 post operativelyResults During 06 hours severity of PONV was comparable in both drug groups but during 2472 hours PONV score 2 was observed in 5 and 175 of patients of group P and group R respectively p0027 While score 3 was observed in 15 of patients of group R and none of the patients of group P p001 On comparison of complete response between Group P and Group R at 06 hours response was almost equal but during 624 hours and 2472 hours number of patient having complete response were more in Group P 975 and 825 as compared to Group R 65 and 57 respectivelyConclusion Palonosetron given as a prophylaxis for postoperative nausea and vomiting PONV in patients undergoing for laparoscopic surgeries seems to have better antiemetic effect over ramosetronKeywords PONV Palonosetron Ramosetron Laparoscopic surgery
Authors and Affiliations
Patel Vaibhavi B, Mehta Vikram P, Agarwal Sameermohan
Keywords
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- EP ID EP476479
- DOI 10.18231/2394-4994.2018.0066
- Views 102
- Downloads 0
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