Comparison of Biochemical Parameters in Saliva with Serum of Chronic Alcoholics: Saliva Can be Used as a Diagnostic Tool in the Future
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 4
Abstract
Alcohol has always been recognized as having a significant impact on the health of the public [1]. Firstly, there has been a focus on the increasing impact of alcoholic liver disease (ALD) in the population as a result of heavy drinking [2]. Secondly, there has been a focusing and concern on alcohol consumption related to crime and violence. Thirty male chronic alcoholics with a history of alcohol abuse for 3-21 years and aged 25-65 years, who were admitted to the De-addiction centre for alcohol withdrawal treatment, were the subjects. Thirty age-matched, non-alcoholics were taken as controls in the study. The subjects were divided into 2 group’s i.e. Group-I was cases and Group-II was controls. Cases were subdivided into 3 group’s i.e. Group-A, Group-B and Group-C. AST, ALT and GGT were assayed in the serum & saliva of thirty chronic alcoholics before, after one and two months post De-addiction treatment. This present study shows increased serum & saliva levels of AST, ALT & GGT in Group-I as compared to Group-II. It was observed that AST, ALT and GGT enzyme activities had significant positive correlation in serum & saliva. Thus, saliva can be used as a diagnostic specimen which has the added advantage over serum as it can be collected repeatedly, in a convenient, minimally invasive manner to make clinical decision & to monitor prognosis.
Authors and Affiliations
B. Vikram, Archana. A. Dharwadkar, Shruti. Mohanty
Keywords
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