Comparison of clinical efficacy of fibrinogen concentrate and cryoprecipitate on severe postpartum hemorrhage in puerpera with placenta accreta
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 4
Abstract
Objective To explore the therapeutic effect of fibrinogen concentrate and cryoprecipitate on severe postpartum hemorrhage in puerpera with placenta accreta under the condition of transfusion of suspended red blood cells and fresh frozen plasma. Methods The clinical data of puerpera with placenta accreta whose blood loss was more than or equal to 50% of the total blood volume within 3 hours in our hospital from January 2009 to June 2021 were retrospectively analyzed. Based on the blood transfusion components, they were divided into fibrinogen concentrate group (group A) and cryoprecipitate group (group B). The coagulation function, blood transfusion units and adverse outcomes of the two groups were analyzed. Results A total of 201 puerpera with severe postpartum hemorrhage due to placenta accreta were included in this study, including 102 cases in group A and 99 cases in group B. The levels of prothrombin time, activated partial thromboplastin time and fibrinogen in group A and group B after blood transfusion were not significantly different from those before delivery (P>0.05). There was no significant difference in blood transfusion volume of suspended red blood cells [(8.18±2.72)U vs (7.90±2.19) U] and fresh frozen plasma [(823.53±258.39)mL vs (804.04±224.94)mL] between group A and group B (P>0.05). There was no significant difference in the incidence of DIC (18.6% vs 21.2%), hysterectomy (26.5% vs 28.3%) and hemorrhagic shock (10.8% vs 13.1%) between group A and group B (P>0.05). Conclusion If puerpera with placenta accreta received both suspended red blood cells and fresh frozen plasma, similar therapeutic effect in severe postpartum hemorrhage was observed between fibrinogen concentrate vs cryoprecipitate. Fibrinogen concentrate has the advantages of rapid preparation, convenient storage and transportation, and can lower the demand for blood products.
Authors and Affiliations
Jingjing LI, Yajuan XU, Miao ZHANG, Qian OUYANG, Yingqi HAO, Bo WU, Zongzong SUN, Yanjie BAN
Keywords
Related Articles
- EP ID EP738528
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.04.008
- Views 62
- Downloads 0
Determination of suspended erythrocyte volume range and establishment of its internal control standard
Objective To determine the volume range of suspended erythrocyte and establish its internal control standard. Methods The theoretical value of suspended erythrocyte volume was calculated according to the screening criter...
Effects of APOBEC3G on the replications of severe fever with thrombocytopenia syndrome virus
Objective To study the effect of apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G)on virus replication and IL-6 production during severe fever with thrombocytopenia syndrome virus (SFTSV) infection. Me...
Clinical outcomes and early immune reconstitution in patients with acute lymphoblastic leukemia underwent allogeneic hematopoietic stem cell transplantation
Objective To investigate the correlation between early immune reconstitution and clinical outcomes in patients with acute lymphoblastic leukemia (ALL) underwent allogeneic hematopoietic stem cell transplantation (allo-HS...
Discussion on the construction of holistic nursing based on SWOT in apheresis platelets collection
Objective To explore the application and effectiveness of holistic nursing based on SWOT in platelet collection at blood stations. Methods SWOT analysis was used to analyze the causes of adverse reactions to blood donati...
Retrospection and multivariate Logistic regression analysis of unqualified blood testing among voluntary blood donors in Guangzhou
Objective To retrospectively analyze the unqualified blood screening results of voluntary blood donors in Guangzhou area during 2016~2020, and analyze various factors that affect the blood screening results, for the purp...