Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines

Journal Title: Advanced Pharmaceutical Bulletin - Year 2013, Vol 3, Issue 1

Abstract

Purpose: Farnesyltransferase (FTase) is a zinc-dependent enzyme that adds a farnesyl group to the Ras proteins. L778, 123 is a potent peptidomimetic imidazole-containing FTase inhibitor. Methods: L778123 was synthesized according to known methods and evaluated alone and in combination with doxorubicin against A549 (adenocarcinomic human alveolar basal epithelial cells) and HT29 (human colonic adenocarcinoma) cell lines by MTT assay. Results: L778123 showed weak cytotoxic activity with IC50 of 100 and 125 for A549 and HT-29 cell lines, respectively. The combination of doxorubicin and L778123 can decrease IC50 of doxorubicin in both cell lines significantly. Conclusion: It can be concluded that L778, 123 can be a good agent for combination therapy.

Authors and Affiliations

Saeed Ghasemi, Soodabeh Davaran, Simin Sharifi, Davoud Asgari, Ali Abdollahi, Javid Shahbazi Mojarrad

Keywords

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  • EP ID EP93271
  • DOI 10.5681/apb.2013.012
  • Views 139
  • Downloads 0

How To Cite

Saeed Ghasemi, Soodabeh Davaran, Simin Sharifi, Davoud Asgari, Ali Abdollahi, Javid Shahbazi Mojarrad (2013). Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Advanced Pharmaceutical Bulletin, 3(1), 73-77. https://www.europub.co.uk/articles/-A-93271