Comparison of Diastolic Function of Homozygous Sickle Cell Anaemia with Haemoglobin AA Children Using Basic Mitral Inflow Doppler Echocardiography
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 22, Issue 12
Abstract
Aims: Sickle cell anaemia (SCA) remains the most prevalent and arduous inherited disease in Nigeria. Various adverse cardiovascular consequences have been documented including cardiac chamber enlargement and left ventricular (LV) hypertrophy. Diastolic dysfunction, a recognized risk factor for death, has been reported in adults however the time of onset remains unknown. A dearth of literature persists about the impact of SCA on diastolic function among children. This study aimed to determine LV diastolic function in children with SCA in steady state and compare with apparently healthy haemoglobin type AA controls. Study Design: Observational, case-controlled, cross-sectional study. Place and Duration of Study: Department of Paediatrics, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife and the Bethesda Heart Centre, Ibadan, Nigeria, six months. Methodology: Fifty subjects aged ≤ 15 years and 50 age- and sex-matched controls to determine and compare basic mitral inflow indices of diastolic function using 2-D guided Doppler echocardiography. Results: Subjects had significantly higher left atrial and LV dimensions, mean E-wave velocity (1.08 versus 0.94 m/ s, p = .001) and A-wave velocity (0.58 versus 0.52 m/ s, p < .001) than controls. Slightly higher E/ A ratio and longer deceleration time were observed in subjects but without statistical significance [p = .48 and p = .33 respectively]. E- and the A-wave velocities in subjects did not correlate with age or BSA unlike in controls which showed negative correlations. There was however significant negative correlation between haematocrit and the A-wave velocity and the E/ A ratio of subjects. Conclusion: Even in steady state, children with SCA have relatively abnormal early and also late LV diastolic filling. These did not correlate with age or BSA. Haematocrit showed significant correlation with late diastolic LV filling. Evaluation of left ventricular diastolic function should be routinely used in cardiac assessment of children with SCA.
Authors and Affiliations
Bamigboye-Taiwo Olukemi, Okeniyi John Akintunde, Omokhodion Samuel, Adeodu Oluwagbemiga, Elusiyan Jerome Boluwaji
Keywords
Related Articles
- EP ID EP312000
- DOI 10.9734/JAMMR/2017/34717
- Views 54
- Downloads 0
Use of Cheiloscopy as a Tool for Gender Dimorphism in a Rural Indian Population
Introduction: The uniqueness of human lip prints can be used for gender dimorphism. Cheiloscopy is an investigational technique under forensic science that deals with the study of uniqueness of lip prints. It has already...
Evaluation of the Efficacy of Topical Timolol Therapy on Oral Lichen Planus: Clinical and Immunohistochemical Study
Aims: To evaluate the efficacies of Timolol topical therapy in patients with atrophic- erosive Oral Lichen Planus (OLP). Study Design: This study was conducted in outpatient clinic of Department of Oral Medicine, Oral D...
Correlation of Clinical and Pathological Parameters with the Diversity and Genetic Evolution of Breast Cancer in Senegalese Women
Aims: The purpose of this study was to assess the hypothesis that genetic diversity of breast cancer is related to clinical and pathological tumors characteristics. Study Design: Representative sequences of mitochondrial...
An Overview of Hutchinson Gilford Progeria Syndrome (HGPS)
Hutchinson Gilford Progeria Syndrome (HGPS) is a rare genetic disorder. The disorder is characterized by premature aging, generally leading to death. The purpose of this article is to review Hutchinson Gilford Progeria S...
A Prospective Drug Utilization Study in Geriatric Hypertensive Patients in a Tertiary Care Hospital, Mumbai
Introduction: The geriatric population assumes great significance in terms of both preventive and curative health care services utilized. The patho-physio-psychological changes associated with ageing make their problems...