COMPARISON OF DILTIAZEM AND LIGNOCAINE IN ATTENUATING THE HAEMODYNAMIC RESPONSES TO ENDOTRACHEAL EXTUBATION
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 18
Abstract
BACKGROUND Endotracheal extubation is one of the frequently performed procedures in the practice of anaesthesia. This study was done to observe the haemodynamic responses during tracheal extubation and to compare the efficacy of Inj. Diltiazem 0.2mg/kg IV vs Inj. Lidocaine 1mg/kg IV in attenuating the haemodynamic responses to tracheal extubation. MATERIALS AND METHODS A double-blind randomised controlled study was conducted on 90 patients aged 20 to 60 years belonging to American society of anaesthesiologists( ASA ) grade I and II patients and were randomly allocated into 3 groups of n=30 each. Group I received normal saline and served as control. Group II received Inj. Diltiazem 0.2mg/kg IV 2mins. before extubation. Group III received Inj. Lidocaine 1mg/kg IV 2mins.before extubation. At the end of the surgery, HR, SBP and DBP were recorded and served as baseline values. HR, SBP and DBP were recorded after giving reversal at 1min. and 2mins. at the time of administration of study drug,1min. after administration of study drug at the time of extubation, after extubation at 1 min.,2 mins., 3 mins., 4 mins., 5 mins. and 20 mins. RESULTS After tracheal extubation, all the haemodynamic parameters increase from the basal level in the control group and decreased in the study group. The change in HR, SBP and DBP were significantly less in group II and group III compared to group I. The change in HR, SBP and DBP were significantly less in group II compared to group III. CONCLUSION Diltiazem hydrochloride, a calcium channel blocker belonging to the benzothiazepine group given in dose of 0.2mg/kg IV, 2mins before tracheal extubation in ASA grade I and grade II patients is a simple, effective and practical method of blunting cardiovascular responses to tracheal extubation. This suppressive effect of diltiazem was comparable to or even more potent than that of lignocaine 1mg/kg IV, 2mins before tracheal extubation.
Authors and Affiliations
Swarnamba U. N, Radha M. K
Keywords
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- EP ID EP215041
- DOI 10.18410/jebmh/2017/206
- Views 134
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