Comparison of effects of Buprenorphine and clonidine as adjuvants to Bupivacaine (0.35%) for supraclavicular brachial plexus block
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 5
Abstract
Background: Adjuvant to local anesthetics have been tried to enhance analgesic profile. Opioids prolonganalgesia but have unfavorable side effect profile. So, search for non-opioid with comparable analgesic durationand minimal side effect continues. Hence our study aims to compare Buprenorphine; an opioid similar instructure to morphine but approx. 33 times more potent, to a novel drug Clonidine; an imidazoline derivative with α2-adrenergic agonistic activity. Settings and Design: A total of 60 patients belonging to ASA status I & II posted for orthopedic upper limbsurgery were enrolled and randomly divided into three Groups of 20 each. All patients received 20ml Bupivacaine (0.5%) in supraclavicular brachial plexus block. Group corresponding adjuvant and normal saline were added to make total solution to 40ml. VAS score and other block characteristics were observed at fixed intervals for 24 hours post operatively.“Graph Pad Prism version 5.03” used for descriptive, analytic and comparative statistics. Results: Onset of sensory block was significantly delayed in clonidine group (Group BC). Analgesia lasted significantly longer in buprenorphine group(Group BB) .VAS scores were found to be better in Group BB and BC and these score was lower than Group B (bupivacaine alone)except at 24 hr. Time to first rescue analgesia and total number of doses were significantly lower in Group BB and Group BC. Incidence of nausea, vomiting and sedation were more in Group BB. Conclusions: Buprenorphine and clonidine are acceptable adjuvants.
Authors and Affiliations
Omer Bashir Itoo, Vasudha Jadhav, Jyotsna Paranjpe
Keywords
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