Comparison of Insulin Tolerance Test with Various Simple and Safe Methods in the Prediction of Insulin Sensitivity
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 1998, Vol 2, Issue 3
Abstract
In the measurement of insulin sensitivity, intravenous insulin tolerance test (IVITT) has been shown to have a high correlation with the euglycemic hyperinsulinemic clamp method. We compared IVITT with levels of plasma Insulin/Glucose ratio (IGR), levels of plasma Insulin/C-peptid ratio (ICR), fasting and 1-h post load insulin levels in 58 nondiabetic obese subjects (Mean BM1: 28.8±1.6 kg/m2, age: 42.8±8.5 years). The glucose levels were determined at 3 min intervals for 15 min after insulin injection. insulin sensitivity was estimated with blood glucose disappearance rate (KITT).KITT 3.51±2.38 % min-1; fasting and post load IGR 35±20, 139±74 pM/mM; fasting and post load ICR 0.14±0.13, 0.25±0.15 pM; fasting and postload 1-h insulin levels were 124.2±48, 882±364 pM, respectively. KITT correlated only with fasting insulin level (r=0.52, p<0.05) and fasting IGR (r= -0.47, p<0.05). Fasting insulin level correlated with 1-h post load insulin level (r=0.58, p<0.05). Fasting IGR correlated with 1-h post load IGR (r=0.55, p<0.05) and fasting ICR (r=0.65, p<0.05). Fasting ICR correlated with 1 -h post load ICR (r=0.67, p<0.001). As a result fasting/postglucose 1 -h insulinaemia has been found very useful in measuring insulin sensitivity, practically. But the ratio of insulinaemia/glycaemia (IGR) appeared to be simple and better method in terms of good correlation with KITT.
Authors and Affiliations
Yüksel Altuntaş, Üstün Korugan, Nezih Hekim
Keywords
Related Articles
- EP ID EP84443
- DOI -
- Views 148
- Downloads 0
Tsunami Ve Diabetes Mellitus: A Story
Editorial
With this issue of our Journal, I will be bidding you farewell as your Editor-in-Chief and will be handing over this responsibility to an elite member of our Society, Prof. Dr. Nilgün Başkal. During the brief period I he...
Subclinical Autonomous Glucocorticoid Hypersecretion
Subclinical autonomous glucocorticoid hypersecretion (SAGH) occurs in patients who have clinically nonfunctioning adrenal adenomas when cortisol secretion becomes autonomous and dysregulated, not fully restrained by pitu...
Türk Diyabetik Hastalarda Yaşam Kalitesinin Değerlendirilmesi
Amaç: Tip 1 ve Tip 2 diabetes mellitus olan hastalarda, diyabetin yaşam kalitesi üzerine etkisinin araştırılması amaçlandı. Gereç ve Yöntem: Çalışmaya 1500 diyabetik (1150 Tip 2 diabetes mellitus, 350 Tip 1 diabetes me...
An Adult Case of Diabetic Ketoacidosis Presenting with Cerebral Edema
Cerebral edema is a life-threatening complication of diabetic ketoacidosis (DKA) which may predominantly develop in pediatric cases during the management of DKA.. Symptomatic cerebral edema in children is rarely detected...