Comparison of Lipid Profile in Normotensive Pregnant Women and Hypertensive Pregnant Women in the Third Trimester

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Comparison of Lipid Profile in Normotensive Pregnant Women and Hypertensive Pregnant Women in the Third Trimester

Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 1

Abstract

Abstract Introduction: Toxemia in pregnancy or Pregnancy Induced Hypertension (PIH) is an idiopathic multisystem disorder specific to human pregnancy. It is a dangerous complication of pregnancy but phasic and is still one of the leading causes of maternal and foetal morbidity and mortality. Aim: The aim of the study was to assess the serum lipid profile in normotensive pregnant women and hypertensive pregnant women in third trimester and to explore the possibility of serum lipid profile as a marker of severity of PIH. Materials and Methods: The present study was conducted on 60 hypertensive (toxemic) (B1-40 pre-eclamptic) (B2-20 eclamptic) pregnant women and 60 normotensive pregnant women (A) of age between 19-35 years and gestational age ranging between ≥28 weeks to term as a case-control study. Serum lipid profile for both the groups were determined using various biochemical kits. Data was subjected to statistical analysis using mean, standard error and student’s t-test etc. A p-value <0.05 was accepted as significant. Results: The mean serum Triglyceride (TG) levels in Group B {Group B1 (266±22.2) and B2 (253.17±21.56)}, Low-density Lipoprotein Cholesterol (LDL-C) levels {Group B1 (134.60±11.32) and B2 (149.30±11.78)} and Very Low-density Lipoprotein Cholesterol (VLDL-C) levels in Group B {Group B1 (49.83±11.76) and B2 (50.16±5.42)} were higher than that in Group A {203±11.9, 124.89±8.11 and 34.94±5.95 respectively} and mean serum Highdensity Lipoprotein Cholesterol (HDL-C) levels in Group B {Group B1 (45.10±5.92) and B2 (44.90±8.31)} were lower than Group A {58.92±5.95 i.e., Hypertensive pregnant women (Group B) as compared to normotensive pregnant women (Group A)}. Conclusion: This study concludes that serum lipid profile can be added as a marker of severity of PIH.

Authors and Affiliations

Mohammad KS Shaikh, Shilpa Mittal

Keywords

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EP ID EP498728
DOI 10.7860/JCDR/2018/27216.11091
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