Comparison of lipid profiles of pre-diabetic and diabetic patients
Journal Title: Santosh University Journal of Health Sciences - Year 2016, Vol 2, Issue 1
Abstract
death in patients with type 2 diabetes mellitus (T2DM).1 Dyslipidemia, frequently occurring in T2DM patients, plays a critical role in the acceleration of macrovascular atherosclerosis and contributes to the excess risk of CVD.2 The dyslipidemia in T2DM is, in general, characterized by elevated triglycerides, reduced high-density lipoprotein (HDL) cholesterol, and predominant presence of small dense low density lipoprotein (sdLDL) particles. Apparently similar abnormalities in serum lipid profiles have also been observed in the pre-diabetic individuals, and the abnormalities are attributed to obesity, hyperinsulinemia and glucose intolerance.3,4 Though pre-diabetes has been associated with an increased risk of CVD events compared to normal, the association is somewhat less than that for overt diabetes.5,6 Apart from the differences in the plasma peak levels of glucose and/or insulin, difference in lipid profiles has also been proposed as a possible explanation for this. However, there is lack of clarity with regard to the nature and extent of this difference.
Authors and Affiliations
MK Bhatnagar, Ritika Sud, Akshay Goel
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